Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.

中文翻译：

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循环游离双链DNA与特发性肺纤维化代谢紊乱的关系


特发性肺纤维化（IPF）是一种进行性、致命性肺部疾病，其病因尚不清楚，病理生理学也知之甚少。尽管 IPF 中循环游离 DNA (ccf-DNA) 的血浆水平和代谢组学变化已有报道，但 ccf-DNA 水平与肺纤维化代谢紊乱之间的关联尚不清楚。在这里，我们证明，与缓慢进展者和健康对照相比，疾病快速进展的 IPF 患者的 ccf-双链 DNA (dsDNA) 增加，并且 ccf-dsDNA 与氨基酸代谢、能量代谢和脂质代谢途径相关。 IPF 患者。