Objectives To determine the association between moderate-to-vigorous intensity physical activity (MVPA) trajectories (course over age and time) through the adult life course and onset of metabolic disease (diabetes and dyslipidaemia). Methods We analysed prospective community-based cohort data of 5115 participants in the Coronary Artery Risk Development in Young Adults study, who were black and white men and women aged 18–30 years at baseline (1985–1986) at four urban sites, collected through 30 years of follow-up. Individualised MVPA trajectories were developed for each participant using linear mixed models. Results Lower estimated MVPA score at age 18 was associated with a 12% (95% CI 6% to 18%) higher odds of incident diabetes, a 4% (95% CI 1% to 7%) higher odds of incident low high-density lipoprotein (HDL) and a 6% (95% CI 2% to 11%) higher odds of incident high triglycerides. Each additional annual 1-unit reduction in the MVPA score was associated with a 6% (95% CI 4% to 9%) higher annual odds of diabetes incidence and a 4% (95% CI 2% to 6%) higher annual odds of high triglyceride incidence. Analysing various MVPA trajectory groups, participants who were in the most active group at age 18 (over 300 min/week), but with sharp declines in midlife, had higher odds of high low-density lipoprotein and low HDL incidence, compared with those in the most active group at age 18 with subsequent gains. Conclusion Given recent trends in declining MVPA across the life course and associated metabolic disease risk, young adulthood is an important time period for interventions to increase and begin the maintenance of MVPA. Data may be obtained from a third party and are not publicly available. Data are available upon request and data use agreement with the CARDIA Study ().

中文翻译：

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从青年期到中年期的中等强度体力活动与代谢疾病：一项基于人群的 30 年队列研究


目的 确定成人生命历程中中等强度体力活动 (MVPA) 轨迹（随年龄和时间变化）与代谢疾病（糖尿病和血脂异常）发病之间的关联。方法 我们分析了年轻人冠状动脉风险发展研究中 5115 名参与者的前瞻性社区队列数据，这些参与者是基线时 (1985-1986) 年龄为 18-30 岁的黑人和白人男性和女性，来自四个城市地点，通过以下方式收集： 30年的追踪。使用线性混合模型为每个参与者开发个性化 MVPA 轨迹。结果 18 岁时估计的 MVPA 评分较低，患糖尿病的几率增加 12%（95% CI 6% 至 18%），患糖尿病的几率增加 4%（95% CI 1% 至 7%）。密度脂蛋白 (HDL) 和发生高甘油三酯的几率增加 6%（95% CI 2% 至 11%）。每年 MVPA 评分每减少 1 个单位，糖尿病发病率每年增加 6%（95% CI 4% 至 9%），年发病率增加 4%（95% CI 2% 至 6%）甘油三酯发生率高。分析各个 MVPA 轨迹组发现，与 18 岁时处于最活跃组（每周超过 300 分钟）但在中年急剧下降的参与者相比，其高低密度脂蛋白和低 HDL 发生率的几率更高。 18 岁时最活跃的群体，并随后取得进展。结论 鉴于近期 MVPA 在整个生命过程中下降的趋势以及相关的代谢疾病风险，成年早期是增加和开始维持 MVPA 干预措施的重要时期。数据可能从第三方获得，并且不公开。数据可根据要求并与 CARDIA 研究签订数据使用协议 () 提供。