Ischemic stroke is a devastating central nervous disease. Despite extensive research in to this area, few innovative neuroprotective treatments have been presented. 7-methoxycoumarin, also known as herniarin, is a common natural coumarin in several plant species. This project examined the effects of the herniarin in rats subjected to the middle cerebral artery occlusion (MCAO). Herniarin at doses of 10 and 20 mg/kg was administered through intraperitoneal injection for 7 days before MCAO induction. Rats were subjected to a 30 min MCAO and a subsequent 24 h’ reperfusion. 24 h after the termination of MCAO, neurologic outcome, volume of brain infarction, level of interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α), as inflammatory markers, and oxidative stress markers including levels of total thiol, malondialdehyde (MDA), and superoxide dismutase (SOD) activity were estimated. Herniarin administration decreased the MCAO-induced infarct volume and neurological deficits. Moreover, pretreatment with herniarin significantly decreased the levels of MDA while simultaneously increasing the level of total thiol and SOD activity in the brain tissues of MCAO rats. Moreover, herniarin pretreatment decreased the levels of IL-1β and TNF-α in the brain tissues of MCAO rats. These results suggest that herniarin presents beneficial effects against ischemic stroke, partly through the inhibition of oxidative stress and inflammation.

缺血性中风是一种破坏性的中枢神经疾病。尽管对该领域进行了广泛的研究，但很少有创新的神经保护疗法被提出。7-甲氧基香豆素，也称为疝气素，是几种植物中常见的天然香豆素。该项目检查了疝气对大脑中动脉闭塞 (MCAO) 大鼠的影响。在 MCAO 诱导前通过腹膜内注射给予 10 和 20 mg/kg 剂量的 Herniarin 7 天。对大鼠进行 30 分钟的 MCAO 和随后的 24 小时再灌注。MCAO 终止后 24 小时，神经系统结果、脑梗死体积、白细胞介素 1β (IL-1β) 和肿瘤坏死因子 α (TNF-α) 水平，作为炎症标志物，以及氧化应激标志物，包括总硫醇水平, 丙二醛 (MDA), 和超氧化物歧化酶（SOD）活性进行了估计。Herniarin 给药减少了 MCAO 诱导的梗塞体积和神经功能缺损。此外，疝素预处理显着降低了 MDA 水平，同时增加了 MCAO 大鼠脑组织中总硫醇和 SOD 活性的水平。此外，疝气素预处理降低了MCAO大鼠脑组织中IL-1β和TNF-α的水平。这些结果表明，疝气对缺血性中风具有有益作用，部分是通过抑制氧化应激和炎症。Herniarin预处理显着降低了MDA水平，同时增加了MCAO大鼠脑组织中总硫醇和SOD活性的水平。此外，疝气素预处理降低了MCAO大鼠脑组织中IL-1β和TNF-α的水平。这些结果表明，疝气对缺血性中风具有有益作用，部分是通过抑制氧化应激和炎症。Herniarin预处理显着降低了MDA水平，同时增加了MCAO大鼠脑组织中总硫醇和SOD活性的水平。此外，疝气素预处理降低了MCAO大鼠脑组织中IL-1β和TNF-α的水平。这些结果表明，疝气对缺血性中风具有有益作用，部分是通过抑制氧化应激和炎症。