Theta-gamma coupling (TGC) is a neurophysiologic mechanism that supports working memory (WM). TGC is associated with N-back performance, a WM task. Similar to TGC, theta and alpha event-related synchronization (ERS) and desynchronization (ERD) are also associated with WM. Few studies have examined the longitudinal relationship between WM performance and TGC, ERS, or ERD. This study aimed to determine if changes in WM performance are associated with changes in TGC (primary aim), as well as theta and alpha ERS or ERD over 6 to 12 weeks. Participants included 62 individuals aged 60 and older with no neuropsychiatric conditions or with remitted Major Depressive Disorder (MDD) and no cognitive disorders. TGC, ERS, and ERD were assessed using electroencephalography (EEG) during the N-back task (3-back condition). There was an association between changes in 3-back performance and changes in TGC, alpha ERD and ERS, and theta ERS in the control group. In contrast, there was only a significant association between changes in 3-back performance and changes in TGC in the subgroup with remitted MDD. Our results suggest that the relationship between WM performance and TGC is stable over time, while this is not the case for changes in theta and alpha ERS and ERD.

中文翻译：

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评估老年人 Theta-Gamma 耦合与工作记忆表现之间的纵向关系


Theta-gamma 耦合 (TGC) 是一种支持工作记忆 (WM) 的神经生理机制。 TGC 与 N-back 性能相关，这是一项 WM 任务。与 TGC 类似，theta 和 alpha 事件相关同步 (ERS) 和去同步 (ERD) 也与 WM 相关。很少有研究探讨 WM 表现与 TGC、ERS 或 ERD 之间的纵向关系。本研究旨在确定 WM 表现的变化是否与 6 至 12 周内 TGC（主要目标）以及 theta 和 alpha ERS ​​或 ERD 的变化相关。参与者包括 62 名 60 岁及以上的人，他们没有神经精神疾病或重度抑郁症 (MDD) 已缓解，但没有认知障碍。在 N-back 任务（3-back 条件）期间使用脑电图 (EEG) 评估 TGC、ERS 和 ERD。在对照组中，三后卫表现的变化与 TGC、α ERD 和 ERS ​​以及 theta ERS ​​的变化之间存在关联。相比之下，在 MDD 缓解的亚组中，三后卫表现的变化与 TGC 的变化之间仅存在显着相关性。我们的结果表明，随着时间的推移，WM 表现与 TGC 之间的关系是稳定的，但 ERS ​​和 ERD 的变化情况并非如此。