To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that hippocampal function can be mapped to anatomically defined substructures, the hippocampal substructure volume can be examined in detail at present. In this study, we examined the volumes of hippocampal substructures between IDs and healthy controls (HC) to accurately find hippocampal markers of ID. First, we used the automated hippocampal substructure module in FreeSurfer6.0 to inspect T1-weighted magnetic resonance images between 22 IDs and 30 HC. Then, 12 hippocampal substructures were computed. Volumetric assessment was performed at the hippocampal substructure level between groups. Our study revealed significant reduced volume of the bilateral fimbria in IDs compared with HC (p < 0.05/12, Bonferroni corrected), although there was no difference in the total volume of hippocampus. In addition, the correlation analysis showed that the total hippocampal volume of the left hemisphere was negatively correlated with Pittsburgh Sleep Quality Index (PSQI) scores. With regard to hippocampal substructure results, negative correlations were detected between bilateral fimbria volume and clinical variables (i.e., PSQI, SDS, and SAS) in all subjects. Taken together, we revealed marked differences in the volume of the hippocampal substructure between IDs and HC, which provided a more accurate structural imaging marker for the pathological of ID.

迄今为止，我们对异常海马体积在失眠症 (ID) 影像学研究中的作用的理解仍然存在明显的矛盾。鉴于海马功能可以映射到解剖学定义的亚结构，目前可以详细检查海马亚结构体积。在这项研究中，我们检查了 ID 和健康对照 (HC) 之间的海马亚结构的体积，以准确找到 ID 的海马标记。首先，我们使用 FreeSurfer6.0 中的自动海马亚结构模块来检查 22 个 ID 和 30 个 HC 之间的 T1 加权磁共振图像。然后，计算了 12 个海马亚结构。在组间海马亚结构水平进行体积评估。我们的研究显示，与 HC 相比，IDs 的双侧菌毛体积显着减少（p  < 0.05/12，Bonferroni 校正），尽管海马体的总体积没有差异。此外，相关性分析显示，左半球海马总体积与匹兹堡睡眠质量指数（PSQI）评分呈负相关。关于海马亚结构结果，在所有受试者中检测到双侧伞毛体积和临床变量（即，PSQI、SDS 和 SAS）之间存在负相关。总之，我们揭示了 ID 和 HC 之间海马亚结构体积的显着差异，这为 ID 的病理提供了更准确的结构成像标记。