Epilepsy is a devastating neurological disorder. Current anti-convulsant drugs are only effective in about 70% of patients, while the rest remain drug-resistant. Thus, alternative methods have been explored to control seizures in these drug-resistant patients. One such method may be through the utilization of fruit phytochemicals. These phytochemicals have been reported to have beneficial properties such as anti-convulsant, anti-oxidant, and anti-inflammatory activities. However, some fruits may also elicit harmful effects. This review aims to summarize and elucidate the anti- or pro-convulsant effects of fruits used in relation to seizures in hopes of providing a good therapeutic reference to epileptic patients and their carers. Three databases, SCOPUS, ScienceDirect, and PubMed, were utilized for the literature search. Based on the PRISMA guidelines, a total of 40 articles were selected for critical appraisal in this review. Overall, the extracts and phytochemicals of fruits managed to effectively reduce seizure activities in various preclinical seizure models, acting mainly through the activation of the inhibitory neurotransmission and blocking the excitatory neurotransmission. Only star fruit has been identified as a pro-convulsant fruit due to its caramboxin and oxalate compounds. Future studies should focus more on utilizing these fruits as possible treatment strategies for epilepsy.

中文翻译：

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癫痫发作的水果？水果及其植物化学物质潜在抗惊厥作用的系统评价。

癫痫是一种破坏性的神经系统疾病。目前的抗惊厥药物仅对约70%的患者有效，其余患者仍存在耐药性。因此，已经探索了替代方法来控制这些耐药患者的癫痫发作。一种这样的方法可能是通过利用水果植物化学物质。据报道，这些植物化学物质具有有益的特性，例如抗惊厥、抗氧化和抗炎活性。然而，一些水果也可能引起有害影响。本综述旨在总结和阐明水果对癫痫发作的抗惊厥或促惊厥作用，以期为癫痫患者及其护理人员提供良好的治疗参考。文献检索使用了 SCOPUS、ScienceDirect 和 PubMed 三个数据库。根据 PRISMA 指南，本次审查共选择了 40 篇文章进行严格评价。总的来说，水果的提取物和植物化学物质成功地在各种临床前癫痫发作模型中有效地减少了癫痫发作活动，主要通过激活抑制性神经传递和阻断兴奋性神经传递起作用。由于杨桃素和草酸盐化合物，只有杨桃被确定为促惊厥水果。未来的研究应该更多地关注利用这些水果作为癫痫的可能治疗策略。主要通过激活抑制性神经传递和阻断兴奋性神经传递起作用。由于杨桃素和草酸盐化合物，只有杨桃被确定为促惊厥水果。未来的研究应该更多地关注利用这些水果作为癫痫的可能治疗策略。主要通过激活抑制性神经传递和阻断兴奋性神经传递起作用。由于杨桃素和草酸盐化合物，只有杨桃被确定为促惊厥水果。未来的研究应该更多地关注利用这些水果作为癫痫的可能治疗策略。