The rationale behind the success of nickel free or with extremely low nickel austenitic high manganese and nitrogen stabilized stainless steels is adverse influences of nickel ion on human body. Replacement of nickel by nitrogen and manganese provides a stable microstructure and facilitates better biocompatibility in respect of the conventional 316L austenitic stainless steel (316L SS). In this investigation, biocompatibility of the high-manganese and nitrogen stabilized (Fe–18Cr–22Mn–0.65N) austenitic stainless steel was studied and found highly promising. In vitro cell culture and cell proliferation (MTT) assays were performed on this stainless steel and assessed in respect of the 316L SS. Both the steels exhibited similar cell growth behavior. Furthermore, an enhancement was observed in cell proliferation on the Fe–18Cr–22Mn–0.65N SS after surface modification by ultrasonic shot peening (USP). The mean percent proliferation of the MG-63 cells increased from ≈88% for Un-USP to 98% and 105% for USP 3–2 and USP 2–2 samples, respectively for 5 d of incubation. Interestingly, in vivo animal study performed in rabbits for 3 and 6 weeks showed callus formation and sign of union without any allergic reaction.

无镍或含镍极低的奥氏体高锰和氮稳定不锈钢成功背后的基本原理是镍离子对人体的不利影响。与传统的 316L 奥氏体不锈钢 (316L SS) 相比，用氮和锰替代镍提供了稳定的微观结构并促进了更好的生物相容性。在这项研究中，研究了高锰和氮稳定的 (Fe-18Cr-22Mn-0.65N) 奥氏体不锈钢的生物相容性，发现其前景广阔。体外对这种不锈钢进行了细胞培养和细胞增殖 (MTT) 分析，并针对 316L SS 进行了评估。两种钢都表现出相似的细胞生长行为。此外，在通过超声喷丸 (USP) 进行表面改性后，在 Fe-18Cr-22Mn-0.65N SS 上观察到细胞增殖增强。MG-63 细胞的平均增殖百分比从 Un-USP 的约 88% 增加到 USP 3-2 和 USP 2-2 样品的 98% 和 105%，孵育 5 天。有趣的是，在兔子中进行 3 周和 6 周的体内动物研究显示愈伤组织形成和愈合迹象，没有任何过敏反应。