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Fat tissue equivalent phantoms for microwave applications by reinforcing gelatin with nanocellulose
Biomedical Physics & Engineering Express ( IF 1.3 ) Pub Date : 2021-10-07 , DOI: 10.1088/2057-1976/ac2634
Hana Dobšíček Trefná 1 , Saül Llàcer Navarro 2, 3 , Fredrik Lorentzon 1, 2 , Tiina Nypelö 2, 3 , Anna Ström 2
Affiliation  

Tissue mimicking phantom materials with thermal and dielectric equivalence are vital for the development of microwave diagnostics and treatment. The current phantoms representing fat tissue are challenged by mechanical integrity at relevant temperatures coupled with complex production protocols. We have employed two types of nanocellulose (cellulose nanocrystals and oxidized cellulose nanocrystals) as reinforcement in gelatin stabilized emulsions for mimicking fat tissue. The nanocellulose-gelatin stabilized emulsions were evaluated for their dielectric properties, the moduli-temperature dependence using small deformation rheology, stress-strain behavior using large deformation, and their compliance to quality assurance guidelines for superficial hyperthermia. All emulsions had low permittivity and conductivity within the lower microwave frequency band, accompanied by fat equivalent thermal properties. Small deformation rheology showed reduced temperature dependence of the moduli upon addition of nanocellulose, independent of type. The cellulose nanocrystals gelatin reinforced emulsion complied with the quality assurance guidelines. Hence, we demonstrate that the addition of cellulose nanocrystals to gelatin stabilized emulsions has the potential to be used as fat phantoms for the development of microwave diagnostics and treatment.



中文翻译:

通过用纳米纤维素增强明胶,用于微波应用的脂肪组织等效体模

具有热和介电等效性的组织模拟模型材料对于微波诊断和治疗的发展至关重要。当前代表脂肪组织的模型受到相关温度下的机械完整性以及复杂的生产协议的挑战。我们采用两种类型的纳米纤维素(纤维素纳米晶体和氧化纤维素纳米晶体)作为明胶稳定乳液中的增强剂,用于模拟脂肪组织。评估了纳米纤维素-明胶稳定乳液的介电性能、使用小变形流变学的模量温度依赖性、使用大变形的应力应变行为以及它们是否符合表面热疗的质量保证指南。所有乳液在较低的微波频带内均具有低介电常数和电导率,并伴有脂肪等效热性能。小变形流变表明添加纳米纤维素后模量的温度依赖性降低,与类型无关。纤维素纳米晶体明胶增强乳液符合质量保证指南。因此,我们证明了在明胶稳定的乳液中添加纤维素纳米晶体有可能用作脂肪体模,用于开发微波诊断和治疗。纤维素纳米晶体明胶增强乳液符合质量保证指南。因此,我们证明了在明胶稳定的乳液中添加纤维素纳米晶体有可能用作脂肪体模,用于开发微波诊断和治疗。纤维素纳米晶体明胶增强乳液符合质量保证指南。因此,我们证明了在明胶稳定的乳液中添加纤维素纳米晶体有可能用作脂肪体模,用于开发微波诊断和治疗。

更新日期:2021-10-07
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