Multipotent hematopoietic stem cells are maintained by the bone marrow niche, but how niche-derived membrane-bound stem cell factor (mSCF) regulates HSCs remains unclear. In this issue, Hao et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010118) describe that mSCF, synergistically with VCAM-1, induces large, polarized protrusions that serve as anchors for HSCs to their niche.

中文翻译：

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造血干细胞的极化锚：干细胞与其生态位之间的突触？

多能造血干细胞由骨髓微环境维持，但微环境衍生的膜结合干细胞因子（mSCF）如何调节造血干细胞仍不清楚。在本期中，郝等人。(2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010118) 描述了 mSCF 与 VCAM-1 协同作用，诱导大的极化突起，作为 HSC 对其生态位的锚定。