Reduced neural responses to reward and pleasant stimuli-indicators of anhedonia and reduced emotional reactivity, respectively-have been reported among individuals with depressive disorders. The current study examined whether these neural measures could prospectively predict the course of depression among a community-based sample of 83 participants diagnosed with a depressive disorder. At initial assessment, participants performed both a guessing task to elicit the reward positivity (RewP) and a picture viewing paradigm with neutral and pleasant pictures to measure the late positive potential (LPP)-both event-related brain potentials (ERPs) independently related to diagnosis of depression. After approximately 9 months, 53 of those participants returned to the lab for a clinical assessment of current symptoms and course of disorder during the follow-up period. We found a more intact (i.e., larger) RewP and LPP at baseline among participants who achieved an episode of full remission from depression at any point during the follow-up period. In multiple logistic regression models, the RewP and LPP were both independent predictors of remission status; moreover, the RewP, but not the LPP, remained a significant predictor after accounting for other clinical variables that predicted remission. These data provide initial evidence for the clinical utility of ERPs from reward and picture viewing tasks within depressed individuals to predict disease course prospectively, which could be further leveraged to improve intervention approaches and parse the heterogeneity of depression. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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对奖励和令人愉快的图片的神经反应前瞻性地预测抑郁症的缓解。

在患有抑郁症的个体中，分别报告了对奖赏和愉悦刺激（快感缺乏症的指标）和情绪反应性降低的神经反应减少。目前的研究检查了这些神经测量是否可以前瞻性地预测 83 名被诊断患有抑郁症的参与者的社区样本中的抑郁症病程。在初始评估中，参与者执行猜测任务以引发奖励积极性 (RewP) 和具有中性和愉快图片的图片查看范式以测量晚期正电位 (LPP)——这两种事件相关的脑电位 (ERP) 均独立于抑郁症的诊断。大约 9 个月后，在随访期间，其中 53 名参与者返回实验室对当前症状和疾病进程进行临床评估。我们发现，在随访期间任何时间点抑郁症完全缓解的参与者的基线 RewP 和 LPP 更完整（即更大）。在多元逻辑回归模型中，RewP 和 LPP 都是缓解状态的独立预测因子；此外，在考虑了其他预测缓解的临床变量后，RewP（而非 LPP）仍然是一个重要的预测因子。这些数据为 ERP 的临床效用提供了初步证据，这些证据来自抑郁个体的奖励和图片查看任务，以前瞻性地预测疾病进程，可以进一步利用它来改进干预方法并解析抑郁症的异质性。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。