Aluminum phosphide is a well-known hazardous agent used as an agricultural pesticide to protect stored grains from insect damage. However, accidental consumption of a trivial amount of it caused irreversible damage to the human body or even death in acute cases. The present study used taurine and grape seed extract as a natural cardioprotective medicine against aluminum phosphide poisoning by decreasing oxidative stress. The activity of oxidative stress biomarkers (Malondialdehyde, Catalase, Protein carbonyl, and Superoxide dismutase) were evaluated in the cell line model on Human Cardiac Myocyte cells. In the beginning, to clarify the pure impact of aluminum phosphide poison, taurine, and grape seed extract on the human heart cells, their effects on the biomarkers quantity in cell line were measured. Subsequently, the effect of taurine and grape seed extract with various concentrations as a treatment on the oxidative stress biomarkers of the poisoned heart cells were studied. Data analysis reveals that taurine and grape seed extract treatment can successfully diminish the poisoning effect by their antioxidant properties. The oxidative markers values of the poisoned cells were recovered by taurine and grape seed extracts treatment. Taurine (2 g/l) can recover Malondialdehyde, Catalase, Protein carbonyl, and Superoxide dismutase by 56%, 78%, 88%, 78%, when the recovering power of grape seed extract (100 g/l) for the aforementioned enzymes are 56%, 0.71%,74%, 51%, respectively. Therefore, it is clear that the performance of taurine in the recovery of the biomarkers’ value is better than grape seed extract.

磷化铝是一种众所周知的危险剂，用作农业杀虫剂以保护储存的谷物免受虫害。然而，不慎食用微量的它，会对人体造成不可逆转的伤害，严重时甚至会导致死亡。本研究使用牛磺酸和葡萄籽提取物作为天然心脏保护药物，通过降低氧化应激来对抗磷化铝中毒。在人心肌细胞的细胞系模型中评估氧化应激生物标志物（丙二醛、过氧化氢酶、羰基蛋白和超氧化物歧化酶）的活性。首先，为了阐明磷化铝毒物、牛磺酸和葡萄籽提取物对人心脏细胞的纯影响，测量了它们对细胞系中生物标志物数量的影响。随后，研究了不同浓度的牛磺酸和葡萄籽提取物对中毒心脏细胞氧化应激生物标志物的影响。数据分析表明，牛磺酸和葡萄籽提取物处理可以通过其抗氧化特性成功减少中毒效应。通过牛磺酸和葡萄籽提取物处理恢复中毒细胞的氧化标记值。当葡萄籽提取物（100 g/l）对上述酶的回收能力时，牛磺酸（2 g/l）可回收丙二醛、过氧化氢酶、蛋白羰基和超氧化物歧化酶56%、78%、88%、78%分别为 56%、0.71%、74%、51%。因此，很明显牛磺酸在生物标志物值的恢复方面的表现优于葡萄籽提取物。