Seawater-source heat pump (SWHP) system exhibits merits of building energy conservation and reducing carbon emissions, while enhancing the heat transfer of seawater heat exchangers is the key to improve the system performance. Here, a model of SWHP system with staggered tube-bundle heat exchanger is established and its performance in winter is numerically studied and verified by experiments. The wave theory is introduced into the mathematical model to describe the flow field of actual ocean and improve the accuracy. The heat transfer performance of staggered tube-bundle exchanger is investigated under icing conditions, and the results indicate that the ice layer thermal resistance outside the tube accounts for more than 28% of the total thermal resistance. The impacts of seawater temperature on the SWHP system performance are discussed and the average increment of heating capacity and COP is 0.12 kW and 0.046 respectively with the increase of seawater temperature by 1 °C. Furthermore, a spatial analysis of SWHP system in 29 coastal cities of China are analyzed and compared with air-source heat pump (ASHP) system. The results show that SWHP system has greater advantages than ASHP system, especially in the southern cities. This research comprehensively analyzes the technology, economy and geography of SWHP system from a more macro perspective, and it can promote the application of ocean thermal energy.