In the present investigation, the effect of mercuric chloride on gestation and lactation periods in mice was studied. The animals were treated with 10 ppm of HgCl₂ and its complications were evaluated by supplementing 150 and 300 ppm of curcumin, respectively. Results indicated that HgCl₂ increased depression-like behavior in treated animals compared to control and effects of depression in offspring significantly (p˂0.001) enhanced. Interestingly, the Tail suspension test clearly confirmed that the administration of curcumin enhanced the immobility (p˂0.001). The results confirmed that the curcumin administered mice spent less time in the closed arm (P < 0.001), whereas spent a very long time (P < 0.001) in the open arm. Related to the locomotor behaviors, number of squares crossed, wall rear, rear, and locomotion duration were decreased significantly (P < 0.001) while immobility duration was increased (P < 0.001) significantly compared to control.

The anxiety and depression behaviors disorder due to mercuric chloride exposure indicated its availability via placenta or/and milk during lactation. The treatment with curcumin improved anxiety and depression behaviors compared to Hg experimental group.

在本研究中，研究了氯化汞对小鼠妊娠期和哺乳期的影响。用 10 ppm HgCl ₂对动物进行治疗，并通过分别补充 150 和 300 ppm 姜黄素来评估其并发症。结果表明，与对照组相比，HgCl ₂增加了治疗动物的抑郁样行为，并且后代抑郁症的影响显着增强（p˂0.001）。有趣的是，尾部悬吊试验清楚地证实了姜黄素的施用增强了不动性（p˂0.001）。结果证实，姜黄素给药的小鼠在闭合臂中花费的时间更少（P  < 0.001），而花费很长时间（P < 0.001) 在开放臂中。与运动行为相关的是，与对照组相比，穿过的方格数、墙壁后部、后部和运动持续时间显着减少（P  < 0.001），而不动持续时间显着增加（P  < 0.001）。

由于氯化汞暴露引起的焦虑和抑郁行为障碍表明其在哺乳期间通过胎盘或/和牛奶获得。与 Hg 实验组相比，姜黄素治疗改善了焦虑和抑郁行为。