Electrochemical sulfonylation of enamides with sodium sulfinates to access β-amidovinyl sulfones,Organic & Biomolecular Chemistry

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Electrochemical sulfonylation of enamides with sodium sulfinates to access β-amidovinyl sulfones
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2021-09-06 , DOI: 10.1039/d1ob01485d
Qingyun Gu ₁ , Xin Wang ₁ , Xinyi Liu ₁ , Guixia Wu ₁ , Yushan Xie ₁ , Yu Shao ₁ , Yu Zhao ₁ , Xiaobao Zeng ₁

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The electrochemical sulfonylation of enamides with sodium sulfinates was developed in an undivided cell in constant current mode, leading to the formation of β-amidovinyl sulfones in moderate to good yields. The catalyst-, electrolyte- and oxidant-free protocol features good functional group tolerance and employs electric current as a green oxidant. Mechanistic insights into the reaction indicate that the reaction may proceed via a radical mechanism.

中文翻译：

用亚磺酸钠对烯酰胺进行电化学磺酰化得到 β-酰胺乙烯基砜

烯酰胺与亚磺酸钠的电化学磺酰化是在恒定电流模式下在未分裂的电池中开发的，从而以中等至良好的产率形成 β-酰胺基乙烯基砜。无催化剂、无电解质和无氧化剂的方案具有良好的官能团耐受性，并采用电流作为绿色氧化剂。对该反应的机理研究表明，该反应可能通过自由基机理进行。

更新日期：2021-09-14

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