Ultra-homogeneous NIR-II fluorescent self-assembled nanoprobe with AIE properties for photothermal therapy of prostate cancer,Nanoscale

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Ultra-homogeneous NIR-II fluorescent self-assembled nanoprobe with AIE properties for photothermal therapy of prostate cancer
Nanoscale ( IF 5.8 ) Pub Date : 2021-09-06 , DOI: 10.1039/d1nr04227k
Shengsheng Cui ₁ , Shanshan Fan ₂ , Haisong Tan ₃ , Yi Lu ₁ , Yiqian Zha ₁ , Bin Xu ₃ , Yanlei Liu ₁ , Daxiang Cui _{1,

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Affiliation

Near-infrared two-zone (NIR-II) fluorescence imaging has attracted attention as a non-invasive imaging technology that provides centimeter-level depth and micron-level resolution. However, producing a NIR-II fluorescent nanoprobe with uniform size, high bio-identical capacity, and fluorescence intensity, while being metabolizable in vivo, remains a challenge. We first produce a hydrophobic NIR-II fluorescent molecule with AIE properties, and subject it to ultrasonic and extrusion treatments to generate a DSPE-PEG-encapsulated NIR-II nanoprobe with an ultra-homogeneous particle size. The current study based on in vitro and mouse tumor-bearing model-based experiments indicate that cancer cells could efficiently take up this nanoprobe, which aggregates in tumor tissues, is susceptible to metabolization, and enables ideal photothermal therapeutic effects. Thus, this NIR-II nanoprobe with AIE properties shows great potential for precise clinical diagnosis and treatment of cancer.

中文翻译：

具有AIE特性的超均匀NIR-II荧光自组装纳米探针用于前列腺癌的光热治疗

近红外二区 (NIR-II) 荧光成像作为一种提供厘米级深度和微米级分辨率的非侵入性成像技术引起了人们的关注。然而，生产具有均匀尺寸、高生物相同容量和荧光强度的 NIR-II 荧光纳米探针，同时可在体内代谢，仍然是一个挑战。我们首先生产具有 AIE 特性的疏水 NIR-II 荧光分子，并对其进行超声波和挤压处理，以生成具有超均匀粒径的 DSPE-PEG 封装的 NIR-II 纳米探针。目前的研究基于体外和基于小鼠肿瘤模型的实验表明，癌细胞可以有效地吸收这种聚集在肿瘤组织中的纳米探针，易于代谢，并实现理想的光热治疗效果。因此，这种具有 AIE 特性的 NIR-II 纳米探针在癌症的精确临床诊断和治疗方面显示出巨大的潜力。

更新日期：2021-09-14

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