Calcium carbonate particles: synthesis, temperature and time influence on the size, shape, phase, and their impact on cell hydroxyapatite formation,Journal of Materials Chemistry B

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Calcium carbonate particles: synthesis, temperature and time influence on the size, shape, phase, and their impact on cell hydroxyapatite formation
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-23 , DOI: 10.1039/d1tb01072g
Sarka Sovova ₁ , Anatolii Abalymov _{2,

3} , Miloslav Pekar ₁ , Andre G Skirtach ₄ , Bogdan Parakhonskiy ₄

Affiliation

To develop materials for drug delivery and tissue engineering and to study their efficiency with respect to ossification, it is necessary to apply physicochemical and biological analyses. The major challenge is labor-intensive data mining during synthesis and the reproducibility of the obtained data. In this work, we investigated the influence of time and temperature on the reaction yield, the reaction rate, and the size, shape, and phase of the obtained product in the completely controllable synthesis of calcium carbonate. We show that calcium carbonate particles can be synthesized in large quantities, i.e., in gram quantities, which is a substantial advantage over previously reported synthesis methods. We demonstrated that the presence of vaterite particles can dramatically stimulate hydroxyapatite (HA) production by providing the continued release of the main HA component – calcium ions – depending on the following particle parameters: size, shape, and phase. To understand the key parameters influencing the efficiency of HA production by cells, we created a predictive model by means of principal component analysis. We found that smaller particles in the vaterite state are best suited for HA growth (HA growth was 8 times greater than that in the control). We also found that the reported dependence of cell adhesion on colloidal particles can be extended to other types of particles that contain calcium ions.

中文翻译：

碳酸钙颗粒：合成、温度和时间对尺寸、形状、相的影响及其对细胞羟基磷灰石形成的影响

为了开发用于药物输送和组织工程的材料并研究它们在骨化方面的效率，有必要应用物理化学和生物分析。主要挑战是合成过程中的劳动密集型数据挖掘和所获得数据的可重复性。在这项工作中，我们研究了在完全可控的碳酸钙合成中，时间和温度对反应收率、反应速率以及所得产物的尺寸、形状和相的影响。我们表明碳酸钙颗粒可以大量合成，即，以克为单位，与先前报道的合成方法相比，这是一个巨大的优势。我们证明，球霰石颗粒的存在可以通过提供主要 HA 成分 - 钙离子 - 的持续释放来显着刺激羟基磷灰石 (HA) 的产生，具体取决于以下颗粒参数：尺寸、形状和相。为了了解影响细胞产生 HA 效率的关键参数，我们通过主成分分析创建了一个预测模型。我们发现球霰石状态的较小颗粒最适合 HA 生长（HA 生长是对照的 8 倍）。我们还发现，报告的细胞粘附对胶体颗粒的依赖性可以扩展到其他类型的含有钙离子的颗粒。

更新日期：2021-09-14

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