The treatment effect of chemotherapeutics is often impeded by nonspecific biodistribution and limited biocompatibility. Polymeric core–shell nanocarriers (PCS NCs) composed of a polymer core and at least one shell have been widely applied for cancer therapy and have shown great potential in selectively delivering chemotherapeutic drugs to tumor sites. These PCS NCs can effectively ameliorate the delivery efficiency and therapeutic index of anticarcinogens by prolonging drug residence in the bloodstream, enhancing tumor tissue drug penetration, facilitating cellular drug uptake, controlling the spatiotemporal release of payloads, or codelivering two or more bioactive agents. This review summarizes recently published literature on using PCS NCs to transport chemotherapeutic drugs with poor aqueous solubility and discusses their design principles, structural features, functional properties, and potential limitations.

化疗药物的治疗效果常常受到非特异性生物分布和有限的生物相容性的阻碍。由聚合物核和至少一个壳组成的聚合物核壳纳米载体（PCS NCs）已广泛应用于癌症治疗，并在选择性地将化疗药物输送到肿瘤部位方面显示出巨大潜力。这些 PCS NCs 可以通过延长药物在血流中的停留时间、增强肿瘤组织药物渗透、促进细胞药物吸收、控制有效载荷的时空释放或共同递送两种或多种生物活性剂来有效改善抗癌药物的递送效率和治疗指数。这篇综述总结了最近发表的关于使用 PCS NCs 运输水溶性较差的化疗药物的文献，并讨论了它们的设计原则，