The delivery of drugs that target ocular tissues is challenging due to the physiological barriers of the eye like tear dilution, nasolacrimal drainage, blinking, tear turnover rate and low residence time Drug-laden contact lenses can be a possible solution to overcome some of these challenges. Nanoparticles are being extensively studied as novel systems for loading drugs into therapeutic contact lenses. The versatile features of the organic and inorganic nanoparticles and their diverse physicochemical properties make it possible to load and sustain drug release from the contact lenses. Nevertheless, several issues remains to be solved before its clinical application and commercialization such as changes in contact lens swelling (water content), transmittance, protein adherence, surface roughness, tensile strength, ion and oxygen permeability and drug leaching during contact lens manufacture. However, clinical studies demonstrated the potential of therapeutic contact lenses to manage the scientific, commercial and regulatory challenges to make its place in the market. This review highlights the different methodologies used to fabricate nanoparticle-laden contact lenses and highlights the major advances and challenges to commercialization.

由于泪液稀释、鼻泪引流、眨眼、泪液周转率和低停留时间等眼睛的生理障碍，靶向眼组织的药物递送具有挑战性。载药隐形眼镜可能是克服其中一些挑战的可能解决方案. 纳米粒子作为将药物装入治疗性隐形眼镜的新型系统正在被广泛研究。有机和无机纳米粒子的多功能特性及其不同的物理化学性质使得从隐形眼镜加载和维持药物释放成为可能。然而，在其临床应用和商业化之前，仍有几个问题有待解决，例如隐形眼镜膨胀（含水量）、透光率、蛋白质粘附、表面粗糙度、拉伸强度、隐形眼镜制造过程中的离子和氧气渗透性以及药物浸出。然而，临床研究证明了治疗性隐形眼镜在应对科学、商业和监管挑战以在市场上占有一席之地的潜力。本综述重点介绍了用于制造载有纳米颗粒的隐形眼镜的不同方法，并重点介绍了商业化的主要进展和挑战。