当前位置：
X-MOL 学术
›
Chem. Bio. Drug Des.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Chromones: Privileged scaffold in anticancer drug discovery
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-09-13 , DOI: 10.1111/cbdd.13951 Vaishali M. Patil 1 , Neeraj Masand 2 , Saroj Verma 3 , Vijay Masand 4
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-09-13 , DOI: 10.1111/cbdd.13951 Vaishali M. Patil 1 , Neeraj Masand 2 , Saroj Verma 3 , Vijay Masand 4
Affiliation
|
In the design and discovery of anticancer drugs, various natural heterocyclic scaffolds have attracted considerable interest as privileged structures. For rational drug design, some of the natural scaffolds such as chromones have exhibited wide acceptability due to their drug-like properties. Among the approved anticancer drugs, the scaffolds with high selectivity for a small group of closely related targets are of importance. In the development of selective anticancer agents, the natural, as well as synthetic, can generate highly selective compounds toward cancer targets. The present manuscript includes more particularly the development of cancer inhibitors incorporating the chromone scaffold, with a strong emphasis on their molecular interactions in the anticancer mechanism. It also includes the structure-activity relationship studies and related examples of lead optimization.
中文翻译：
Chromones：抗癌药物发现中的特权支架
在抗癌药物的设计和发现中，各种天然杂环支架作为特权结构引起了相当大的兴趣。对于合理的药物设计，一些天然支架（如色酮）由于其类似药物的特性而表现出广泛的可接受性。在已获批的抗癌药物中，对一小组密切相关的靶点具有高选择性的支架具有重要意义。在开发选择性抗癌剂时，天然的和合成的都可以产生针对癌症靶标的高选择性化合物。本手稿更具体地包括结合色酮支架的癌症抑制剂的开发，重点强调它们在抗癌机制中的分子相互作用。
更新日期：2021-10-29
中文翻译：
Chromones：抗癌药物发现中的特权支架
在抗癌药物的设计和发现中，各种天然杂环支架作为特权结构引起了相当大的兴趣。对于合理的药物设计，一些天然支架（如色酮）由于其类似药物的特性而表现出广泛的可接受性。在已获批的抗癌药物中，对一小组密切相关的靶点具有高选择性的支架具有重要意义。在开发选择性抗癌剂时，天然的和合成的都可以产生针对癌症靶标的高选择性化合物。本手稿更具体地包括结合色酮支架的癌症抑制剂的开发，重点强调它们在抗癌机制中的分子相互作用。
京公网安备 11010802027423号