Desolvation of Peptide Bond by O to S Substitution Impacts Protein Stability,Angewandte Chemie International Edition

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Desolvation of Peptide Bond by O to S Substitution Impacts Protein Stability
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-14 , DOI: 10.1002/anie.202110978
Bhavesh Khatri ₁ , Shampa Raghunathan _{2,

3} , Sohini Chakraborti ₁ , R Rahisuddin ₄ , S Kumaran ₄ , Raghu Tadala ₅ , Padmakar Wagh ₅ , U Deva Priyakumar ₂ , Jayanta Chatterjee ₁

Affiliation

A C=O to C=S substitution in the amide bond dramatically alters the water structure around the thioamide bond, ultimately reducing the microenvironment polarity. The increased hydrophobicity of the modified peptide bond is utilized to amplify the thermostability of proteins by this single atom substitution.