The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity to examine patient thrombus material. Increasing evidence indicates that stroke thrombi are complex and heterogenous, consisting of various biochemical (eg, fibrin, von Willebrand Factor, and neutrophil extracellular traps) and cellular (eg, red blood cells, platelets, leukocytes, and bacteria) components. This complex composition may explain therapeutic limitations and also offer novel insights in several aspects of stroke management. Better understanding of thrombus characteristics could, therefore, potentially lead to improvements in the management of patients with stroke. In this review, we provide a comprehensive overview of the lessons learned by examining stroke thrombus composition after endovascular thrombectomy and its potential relevance for thrombectomy success rates, thrombolysis, clinical outcomes, stroke etiology, and radiological imaging.

中文翻译：

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研究血栓切除术后的中风血栓成分：我们能学到什么？

近年来，缺血性中风血栓的成分引起了越来越多的关注。标准中风护理中血管内手术的实施为研究人员提供了检查患者血栓物质的独特机会。越来越多的证据表明，中风血栓是复杂且异质的，由各种生化成分（例如纤维蛋白、血管性血友病因子和中性粒细胞胞外陷阱）和细胞成分（例如红细胞、血小板、白细胞和细菌）组成。这种复杂的成分可以解释治疗的局限性，并为中风治疗的多个方面提供新的见解。因此，更好地了解血栓特征可能会改善中风患者的治疗。在这篇综述中，我们全面概述了通过检查血管内血栓切除术后中风血栓成分所吸取的经验教训，及其与血栓切除成功率、溶栓、临床结果、中风病因和放射学成像的潜在相关性。