Aims: The study aims at evaluating the effects of the combinatory famotidine/cimetidine diet on radiated mice's survival.
Materials and Methods: Two hundred and seventy male mice were categorized into 11 groups, a number of which were comprised of subgroups too. The groups under analysis were posed to varying doses of gamma-radiation, including 6, 7, 8, and 9 Gy, followed by treatments using various drug doses 2, 4, and 8 mg/kg, with survival fractions as long as a month after irradiation being measured and recorded.
Results: LD_50/30 was calculated as 7.47 Gy for the group with radiation only. Following mouse treatment with a concentration of 4 and 20 mg/kg for famotidine and cimetidine, respectively, the survival fraction for the mice grew significantly compared to LD_50/30. The combinatory famotidine/cimetidine diet had a higher dose-reduction factor (DRF) than single doses of the drug in radioprotection. The DRF for combinatory famotidine/cimetidine, famotidine, and cimetidine diets was 08.09, 1.1, and 1.01, respectively.
Conclusions: Results imply that the combined regimen of famotidine + cimetidine in radioprotection had no significant higher DRF than with regimens including each of them separately. In addition, we did not find a synergic effect of combined oral famotidine and cimetidine on irradiated mice.


中文翻译：

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口服法莫替丁和西咪替丁对致死性辐照小鼠生存的联合作用：一项体内研究


目的：本研究旨在评估法莫替丁/西咪替丁联合饮食对受辐射小鼠生存的影响。
材料与方法：将270只雄性小鼠分为11组，其中一些还包括亚组。接受分析的各组接受不同剂量的伽马射线照射，包括 6、7、8 和 9 Gy，然后使用 2、4 和 8 mg/kg 的各种药物剂量进行治疗，存活分数长达一个月辐照后进行测量和记录。
结果： LD _50/30仅辐射组计算为 7.47 Gy。_{在分别以 4 和 20 mg/kg 的浓度对法莫替丁和西咪替丁进行小鼠治疗后，与 LD 50/30}相比，小鼠的存活率显着增加。在放射防护中，法莫替丁/西咪替丁联合饮食比单剂量药物具有更高的剂量减少因子 (DRF)。法莫替丁/西咪替丁、法莫替丁和西咪替丁联合饮食的 DRF 分别为 08.09、1.1 和 1.01。
结论：结果表明，法莫替丁 + 西咪替丁联合方案在放射防护方面的 DRF 不显着高于分别包含它们的方案。此外，我们没有发现联合口服法莫替丁和西咪替丁对辐照小鼠有协同作用。