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Magnetic resonance imaging for the study of mediastinal adenopathies in lung cancer: Comparison with standard tests
Journal of Cancer Research and Therapeutics ( IF 1.3 ) Pub Date : 2021-07-01 , DOI: 10.4103/jcrt.jcrt_1626_20 Tara Pereiro-Brea 1 , Anxo Martínez de Alegría 2 , Luis Valdés 3 , Antonio Golpe-Gómez 4 , José Martín Carreira-Villamor 5 , Alberto Ruano-Raviña 6
Background: Lung cancer is the second most common cancer in both men and women. Mediastinal lymph node involvement in these patients, determined by imaging tests, indicates prognosis and modifies therapeutic attitude.
Purpose: The aim of this study was to analyze the diagnostic capacity of magnetic resonance imaging (MRI) in the study of the mediastinum in comparison with conventional tests (computed tomography [CT] and positron-emission tomography [PET] or PET/CT scans), taking histology as the gold standard.
Materials and Methods: An observational study was conducted on 16 patients with suspicion of primary lung cancer (June 2016 through December 2018). We studied their demographic characteristics and used CT, PET, or PET/CT scans and MRI (diffusion-weighted imaging-MRI sequence) to examine mediastinal disease and compare MRIs diagnostic yield and percentage agreement to that of conventional tests.
Results: As compared to CT and PET scanning, MRI displayed a very low sensitivity and a specificity of 90 and 88%, respectively; positive predictive value was 0.67 (both) and negative predictive value (NPV) was 0.28 and 0.22, respectively. MRI showed a high degree of agreement in lymph node diagnosis when compared with histology (91.2%; P = 0.001): specificity in this case was high (E = 0.94), as was the NPV (NPV = 0.97).
Conclusions: The results of this study would appear to indicate that MRI could play a relevant role in mediastinal staging of lung cancer. More prospective, multicenter studies are, however, needed to be able to draw up firm recommendations about the role of MRI and its place in lung cancer staging.
中文翻译：
用于研究肺癌纵隔腺病的磁共振成像：与标准测试的比较
背景：肺癌是男性和女性中第二常见的癌症。这些患者的纵隔淋巴结受累，通过影像学检查确定，表明预后并改变治疗态度。
目的：本研究的目的是分析磁共振成像 (MRI) 在纵隔研究中的诊断能力，并与常规检查（计算机断层扫描 [CT] 和正电子发射断层扫描 [PET] 或 PET/CT 扫描）进行比较。 )，以组织学为金标准。
材料和方法：对 16 名疑似原发性肺癌的患者（2016 年 6 月至 2018 年 12 月）进行了一项观察性研究。我们研究了他们的人口统计学特征，并使用 CT、PET 或 PET/CT 扫描和 MRI（弥散加权成像-MRI 序列）检查纵隔疾病，并将 MRI 的诊断率和百分比一致性与常规检查进行比较。
结果：与 CT 和 PET 扫描相比，MRI 的敏感性非常低，特异性分别为 90% 和 88%；阳性预测值为 0.67（两者），阴性预测值 (NPV) 分别为 0.28 和 0.22。与组织学相比，MRI 显示淋巴结诊断高度一致（91.2%；P= 0.001)：这种情况下的特异性很高 (E = 0.94)，NPV (NPV = 0.97) 也是如此。
结论：这项研究的结果似乎表明 MRI 可能在肺癌的纵隔分期中发挥相关作用。然而，需要更多的前瞻性、多中心研究来制定关于 MRI 的作用及其在肺癌分期中的地位的明确建议。
更新日期：2021-07-01
Journal of Cancer Research and Therapeutics ( IF 1.3 ) Pub Date : 2021-07-01 , DOI: 10.4103/jcrt.jcrt_1626_20 Tara Pereiro-Brea 1 , Anxo Martínez de Alegría 2 , Luis Valdés 3 , Antonio Golpe-Gómez 4 , José Martín Carreira-Villamor 5 , Alberto Ruano-Raviña 6
Affiliation
Background: Lung cancer is the second most common cancer in both men and women. Mediastinal lymph node involvement in these patients, determined by imaging tests, indicates prognosis and modifies therapeutic attitude.
Purpose: The aim of this study was to analyze the diagnostic capacity of magnetic resonance imaging (MRI) in the study of the mediastinum in comparison with conventional tests (computed tomography [CT] and positron-emission tomography [PET] or PET/CT scans), taking histology as the gold standard.
Materials and Methods: An observational study was conducted on 16 patients with suspicion of primary lung cancer (June 2016 through December 2018). We studied their demographic characteristics and used CT, PET, or PET/CT scans and MRI (diffusion-weighted imaging-MRI sequence) to examine mediastinal disease and compare MRIs diagnostic yield and percentage agreement to that of conventional tests.
Results: As compared to CT and PET scanning, MRI displayed a very low sensitivity and a specificity of 90 and 88%, respectively; positive predictive value was 0.67 (both) and negative predictive value (NPV) was 0.28 and 0.22, respectively. MRI showed a high degree of agreement in lymph node diagnosis when compared with histology (91.2%; P = 0.001): specificity in this case was high (E = 0.94), as was the NPV (NPV = 0.97).
Conclusions: The results of this study would appear to indicate that MRI could play a relevant role in mediastinal staging of lung cancer. More prospective, multicenter studies are, however, needed to be able to draw up firm recommendations about the role of MRI and its place in lung cancer staging.
中文翻译：
用于研究肺癌纵隔腺病的磁共振成像：与标准测试的比较
背景：肺癌是男性和女性中第二常见的癌症。这些患者的纵隔淋巴结受累，通过影像学检查确定，表明预后并改变治疗态度。
目的：本研究的目的是分析磁共振成像 (MRI) 在纵隔研究中的诊断能力，并与常规检查（计算机断层扫描 [CT] 和正电子发射断层扫描 [PET] 或 PET/CT 扫描）进行比较。 )，以组织学为金标准。
材料和方法：对 16 名疑似原发性肺癌的患者（2016 年 6 月至 2018 年 12 月）进行了一项观察性研究。我们研究了他们的人口统计学特征，并使用 CT、PET 或 PET/CT 扫描和 MRI（弥散加权成像-MRI 序列）检查纵隔疾病，并将 MRI 的诊断率和百分比一致性与常规检查进行比较。
结果：与 CT 和 PET 扫描相比，MRI 的敏感性非常低，特异性分别为 90% 和 88%；阳性预测值为 0.67（两者），阴性预测值 (NPV) 分别为 0.28 和 0.22。与组织学相比，MRI 显示淋巴结诊断高度一致（91.2%；P= 0.001)：这种情况下的特异性很高 (E = 0.94)，NPV (NPV = 0.97) 也是如此。
结论：这项研究的结果似乎表明 MRI 可能在肺癌的纵隔分期中发挥相关作用。然而，需要更多的前瞻性、多中心研究来制定关于 MRI 的作用及其在肺癌分期中的地位的明确建议。
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