Organic–inorganic nanocomposites for photothermal therapy of cancers emerged as a promising strategy against malignant tumors. However, it is still a big challenge to develop a nanocomposite system that can maximize the synergistic photo-thermal therapy effect as well as preserve high stability for simultaneous delivery of the chemotherapeutic drugs and photo-thermal agents. Here, we have exploited an organic liposome containing inorganic core for co-loading the aggregates of bovine serum albumin (BSA), indocyanine green (ICG), and doxorubicin (DOX), abbreviated as BID-liposomal nanocomposites. The three kinds of substances were aggregated in the core of liposomal nanocomposites through hydrophobic and electrostatic interactions. In vitro characterization shows that BID-liposomal nanocomposites were spherical nanoparticles with size of 30–50 nm and good storage stability. Moreover, BID-Liposomal nanocomposites illustrate the strongest cytotoxicity among all the formulations against murine 4T1 tumor cells. In breast cancer-bearing mouse models, BID liposomes lead to significant improvements in tumor inhibition effects with no obvious toxicity. Therefore, the BID-liposomal nanoparticle is believed to be a promising strategy for chemo-photo-thermal therapy against cancers.

用于癌症光热治疗的有机-无机纳米复合材料成为对抗恶性肿瘤的一种有前途的策略。然而，开发一种纳米复合系统仍然是一个巨大的挑战，它可以最大限度地发挥协同光热治疗效果，同时保持化疗药物和光热剂同时输送的高稳定性。在这里，我们开发了一种含有无机核的有机脂质体，用于共同加载牛血清白蛋白 (BSA)、吲哚菁绿 (ICG) 和阿霉素 (DOX) 的聚集体，缩写为 BID-脂质体纳米复合材料。这三种物质通过疏水和静电相互作用聚集在脂质体纳米复合材料的核心中。体外表征表明，BID-脂质体纳米复合材料是球形纳米颗粒，尺寸为30-50 nm，具有良好的储存稳定性。此外，BID-脂质体纳米复合材料在所有制剂中对鼠 4T1 肿瘤细胞的细胞毒性最强。在携带乳腺癌的小鼠模型中，BID 脂质体显着改善了肿瘤抑制作用，且无明显毒性。因此，BID-脂质体纳米颗粒被认为是针对癌症的化学光热疗法的一种有前途的策略。