Frontiers in Materials ( IF 2.6 ) Pub Date : 2021-09-14 , DOI: 10.3389/fmats.2021.710187 Haibin Liu , Feng Zhuang , Chengjian Zhang , Wanzhao Ai , Wei Liu , Xukun Zhou
Organic–inorganic nanocomposites for photothermal therapy of cancers emerged as a promising strategy against malignant tumors. However, it is still a big challenge to develop a nanocomposite system that can maximize the synergistic photo-thermal therapy effect as well as preserve high stability for simultaneous delivery of the chemotherapeutic drugs and photo-thermal agents. Here, we have exploited an organic liposome containing inorganic core for co-loading the aggregates of bovine serum albumin (BSA), indocyanine green (ICG), and doxorubicin (DOX), abbreviated as BID-liposomal nanocomposites. The three kinds of substances were aggregated in the core of liposomal nanocomposites through hydrophobic and electrostatic interactions.
中文翻译:
用于有效光热治疗乳腺癌的功能化有机-无机脂质体纳米复合材料
用于癌症光热治疗的有机-无机纳米复合材料成为对抗恶性肿瘤的一种有前途的策略。然而,开发一种纳米复合系统仍然是一个巨大的挑战,它可以最大限度地发挥协同光热治疗效果,同时保持化疗药物和光热剂同时输送的高稳定性。在这里,我们开发了一种含有无机核的有机脂质体,用于共同加载牛血清白蛋白 (BSA)、吲哚菁绿 (ICG) 和阿霉素 (DOX) 的聚集体,缩写为 BID-脂质体纳米复合材料。这三种物质通过疏水和静电相互作用聚集在脂质体纳米复合材料的核心中。