People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-induced) diabetes model was employed to investigate influenza-induced cardiac distress. Lung histopathology and viral titres revealed no difference in respiratory severity between infected control and diabetic mice. However, compared with infected control mice, infected diabetic mice had increased serum cardiac troponin I and creatine-kinase MB, left ventricular structural changes and right ventricular functional alterations, providing the first experimental evidence of type I diabetes increasing risks of influenza-induced cardiovascular complications.

糖尿病患者易患心血管疾病和严重的甲型流感病毒感染。我们假设糖尿病也会增加流感相关心脏并发症的风险。小鼠 1 型（链脲佐菌素诱导）糖尿病模型用于研究流感诱导的心脏窘迫。肺组织病理学和病毒滴度显示受感染的对照小鼠和糖尿病小鼠的呼吸严重程度没有差异。然而，与受感染的对照小鼠相比，受感染的糖尿病小鼠血清心肌肌钙蛋白 I 和肌酸激酶 MB、左心室结构变化和右心室功能改变，提供了 I 型糖尿病增加流感引起的心血管并发症风险的第一个实验证据.