Purpose: To detect lung metastases, we conducted a retrospective study to improve patient prognosis.

Methods: Hypertension patients with ocular metastases (OM group; n = 58) and without metastases (NM group; n = 1,217) were selected from individuals with lung cancer admitted to our hospital from April 2005 to October 2019. The clinical characteristics were compared by Student's t-test and chi-square test. Independent risk factors were identified by binary logistic regression, and their diagnostic value evaluated by receiver operating characteristic curve analysis.

Results: Age and sex did not differ significantly between OM and NM groups; There were significant differences in pathological type and treatment. Adenocarcinoma was the main pathological type in the OM group (67.24%), while squamous cell carcinoma was the largest proportion (46.43%) in the NM group, followed by adenocarcinoma (34.10%). The OM group were treated with chemotherapy (55.17%), while the NM group received both chemotherapy (39.93%) and surgical treatment (37.06%). Significant differences were detected in the concentrations of cancer antigen (CA)−125, CA-199, CA-153, alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fraction 21-1 (CYFRA21-1), total prostate-specific antigen, alkaline phosphatase, and hemoglobin (Student's t-test). Binary logistic regression analysis indicated that CA-199, CA-153, AFP, CEA, and CYRFA21-1 were independent risk factors for lung cancer metastasis. AFP (98.3%) and CEA (89.3%) exhibited the highest sensitivity and specificity, respectively, while CYRFA21-1 had the highest area under the ROC curve value (0.875), with sensitivity and specificity values of 77.6 and 87.0%, respectively. Hence, CYFRA21-1 had the best diagnostic value.

目的： 为了检测肺转移，我们进行了一项回顾性研究以改善患者预后。

方法： 合并眼转移的高血压患者（OM组； n = 58) 且无转移（NM 组； n = 1,217) 选自 2005 年 4 月至 2019 年 10 月我院收治的肺癌患者。 吨- 检验和卡方检验。通过二元逻辑回归确定独立危险因素，并通过受试者工作特征曲线分析评估其诊断价值。

结果：OM 和 NM 组之间的年龄和性别没有显着差异；病理类型和治疗有显着差异。OM组主要病理类型为腺癌（67.24%），NM组鳞状细胞癌比例最大（46.43%），其次是腺癌（34.10%）。OM组接受化疗（55.17%），NM组接受化疗（39.93%）和手术治疗（37.06%）。在癌抗原（CA）-125、CA-199、CA-153、甲胎蛋白（AFP）、癌胚抗原（CEA）、细胞角蛋白部分21-1（CYFRA21-1）、总前列腺-特异性抗原、碱性磷酸酶和血红蛋白（学生的吨-测试）。二元logistic回归分析表明CA-199、CA-153、AFP、CEA和CYRFA21-1是肺癌转移的独立危险因素。AFP（98.3%）和CEA（89.3%）分别表现出最高的敏感性和特异性，而CYRFA21-1的ROC曲线下面积值最高（0.875），敏感性和特异性值分别为77.6%和87.0%。因此，CYFRA21-1 具有最好的诊断价值。