Introduction and Objective: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. Methods: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2′-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. Results: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164–222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199–1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. Conclusion: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.
Obes Facts

中文翻译：

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妊娠期体重增加会影响妊娠期间的脂肪因子-氧化应激关联

引言和目的：怀孕期间增加的体重可以决定母子二人近期和未来的健康状况。异常脂肪组织 (AT) 积累导致的妊娠期体重过度增加 (EGWG) 与围产期不良结局密切相关，如妊娠期糖尿病、巨大儿、肥胖和高血压。脂肪因子失调、AT 功能障碍和促氧化-抗氧化系统失衡是 AT 积累改变的关键特征。本研究旨在调查孕妇脂肪因子和氧化应激标志物之间的关联以及 GWG 对这种关联的影响。方法：在妊娠晚期（ n= 74) 和血清脂肪因子（脂联素、瘦素和抵抗素），氧化损伤标志物：8-oxo-2'-脱氧鸟苷 (8-oxodG)、脂氢过氧化物 (LOOH)、丙二醛 (MDA) 和羰基化蛋白 (CP)，和葡萄糖作为代谢标志物进行了测量。结果： EGWG 女性的脂联素水平低于体重增加充足 (AWG) 或体重增加不足 (IWG) 的女性。多元线性回归模型显示，AWG ( B = 1.09, 95% CI: 164–222, p = 0.027) 和 IWG ( B = 0.860, 95% CI: 0.199–1.52, p = 0.013），但在患有 EGWG 的女性中没有。在患有 EGWG 的女性中，瘦素与 LOOH 呈正相关（p= 0.018)、MDA ( p = 0.005) 和 CP ( p = 0.010) 氧化标记。结论：我们的研究结果表明，同时存在调节孕妇脂肪因子产生和氧化应激的机制，这种调节受 GWG 的影响，可能是由于 AT 积累过多。
肥胖事实