Aleutian mink disease virus (AMDV) is known to cause the most significant disease in the mink industry. It is globally widespread and manifested as a deadly plasmacytosis and hyperglobulinemia. So far, measures to control the viral spread have been limited to manual serological testing for AMDV-positive mink. Further, due to the persistent nature of this virus, attempts to eradicate Aleutian disease (AD) have largely failed. Therefore, effective strategies to control the viral spread are of crucial importance for wildlife protection. One potentially key tool in the fight against this disease is by the immunization of mink against AMDV. Throughout many years, several researchers have tried to develop AMDV vaccines and demonstrated varying degrees of protection in mink by those vaccines. Despite these attempts, there are currently no vaccines available against AMDV, allowing the continuation of the spread of Aleutian disease. Herein, we summarize previous AMDV immunization attempts in mink as well as other preventative measures with the purpose to shed light on future studies designing such a potentially crucial preventative tool against Aleutian disease.

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AMDV 疫苗：挑战和前景

众所周知，阿留申水貂病病毒 (AMDV) 会导致水貂业最严重的疾病。它在全球广泛分布，表现为致命的浆细胞增多症和高球蛋白血症。到目前为止，控制病毒传播的措施仅限于对 AMDV 阳性水貂进行手动血清学检测。此外，由于这种病毒的持久性，根除阿留申病 (AD) 的尝试在很大程度上失败了。因此，控制病毒传播的有效策略对于野生动物保护至关重要。与这种疾病作斗争的一个潜在关键工具是水貂对 AMDV 的免疫接种。多年来，一些研究人员试图开发 AMDV 疫苗，并证明了这些疫苗对水貂的不同程度的保护。尽管有这些尝试，目前没有针对 AMDV 的疫苗，这使得阿留申病继续传播。在此，我们总结了以前在水貂中进行的 AMDV 免疫尝试以及其他预防措施，旨在阐明未来研究设计这种针对阿留申病的潜在关键预防工具的研究。