Controlling populations of free-roaming dogs and cats poses a huge challenge worldwide. Non-surgical neutering strategies for male animals have been long pursued, but the implementation of the procedures developed has remained limited to date. As submitting the testes to high temperatures impairs spermatogenesis, the present study investigated localized application of magnetic nanoparticle hyperthermia (MNH) to the testicles as a potential non-surgical sterilization method for animals. An intratesticular injection of a magnetic fluid composed of manganese-ferrite nanoparticles functionalized with citrate was administered followed by testicle exposure to an alternate magnetic field to generate localized heat. Testicular MNH was highly effective, causing progressive seminiferous tubule degeneration followed by substitution of the parenchyma with stromal tissue and gonadal atrophy, suggesting an irreversible process with few side effects to general animal health.

中文翻译：

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使用磁性纳米粒子热疗对雄性动物进行绝育的新前景

控制自由漫游的狗和猫的数量在世界范围内构成了巨大的挑战。长期以来，人们一直在追求雄性动物的非手术绝育策略，但迄今为止，所开发的程序的实施仍然有限。由于将睾丸置于高温下会损害精子发生，本研究调查了磁性纳米粒子热疗 (MNH) 对睾丸的局部应用，作为一种潜在的动物非手术绝育方法。在睾丸内注射由用柠檬酸功能化的锰-铁氧体纳米颗粒组成的磁流体，然后将睾丸暴露在交替磁场中以产生局部热量。睾丸 MNH 非常有效，