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Cover Feature: Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives (Eur. J. Org. Chem. 36/2021)
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-09-13 , DOI: 10.1002/ejoc.202101108 Kristaps Leškovskis 1 , Jānis Miķelis Zaķis 1 , Irina Novosjolova 1 , Māris Turks 1
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-09-13 , DOI: 10.1002/ejoc.202101108 Kristaps Leškovskis 1 , Jānis Miķelis Zaķis 1 , Irina Novosjolova 1 , Māris Turks 1
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The Cover Feature shows the essence of purine ring opening pathways. Electrophilic activation of purine by pulling its electron density from N(1) or N(7) and subsequent nucleophile attack ensures the ring-opening of the pyrimidine or imidazole part of the parent heterocycle. The obtained products can be used as such or submitted to further rearrangements and cyclizations. This methodology is a useful addition to the synthetic toolbox of heterocyclic chemistry. More information can be found in the Review by I. Novosjolova, M. Turks et al.
中文翻译：
封面特写：嘌呤开环在咪唑、嘧啶和新型嘌呤衍生物合成中的应用（Eur. J. Org. Chem. 36/2021）
Cover Feature展示了嘌呤环打开通路的本质。通过从 N(1) 或 N(7) 中拉动其电子密度和随后的亲核试剂攻击来亲电激活嘌呤，确保母体杂环的嘧啶或咪唑部分的开环。获得的产物可以原样使用或进行进一步的重排和环化。这种方法是对杂环化学合成工具箱的有用补充。更多信息可以在 I. Novosjolova、M. Turks 等人的评论中找到。
更新日期：2021-09-27
中文翻译：
封面特写：嘌呤开环在咪唑、嘧啶和新型嘌呤衍生物合成中的应用（Eur. J. Org. Chem. 36/2021）
Cover Feature展示了嘌呤环打开通路的本质。通过从 N(1) 或 N(7) 中拉动其电子密度和随后的亲核试剂攻击来亲电激活嘌呤，确保母体杂环的嘧啶或咪唑部分的开环。获得的产物可以原样使用或进行进一步的重排和环化。这种方法是对杂环化学合成工具箱的有用补充。更多信息可以在 I. Novosjolova、M. Turks 等人的评论中找到。
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