Involvement of basophils in chronic spontaneous urticaria (CSU) immunopathogenesis is suggested by the blood basopenia that correlates with disease activity and may result from circulating basophils moving to cutaneous sites of wheals.¹ The humanized IgG₁k monoclonal antibody omalizumab binds to the Cε3 domain of Fc on the IgE heavy chain leading to rapid reduction in free IgE levels and subsequent decrease in FcεRI expression on basophils and mast cells.

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对奥马珠单抗有反应的慢性自发性荨麻疹患者独特的嗜碱性粒细胞 microRNA 特征

嗜碱性粒细胞参与慢性自发性荨麻疹 (CSU) 的免疫发病机制由与疾病活动相关的血碱减少提示，这可能是由于循环嗜碱性粒细胞移动到风团的皮肤部位所致。¹人源化 IgG ₁ k 单克隆抗体奥马珠单抗与 IgE 重链上 Fc 的 Cε3 结构域结合，导致游离 IgE 水平快速降低，随后嗜碱性粒细胞和肥大细胞上 FcεRI 表达降低。