Fruit development is modified by different types of epigenetics. Histone methylation is an important way of epigenetic modification. Eight genes related to H3K4 methyltransferase, named VvH3K4s, were identified and isolated from the grape genome based on conserved domain analysis, which could be divided into 3 categories by the phylogenetic relationship. Transcriptome data showed that VvH3K4–5 was obviously up-regulated during fruit ripe, and its expression level was significantly different between ‘Kyoho’ and ‘Fengzao’. The VvH3K4s promoters contains cis-acting elements of in response to stress, indicating that they may be involved in the metabolic pathways regulated by ROS signaling. The subcellular localization experiment and promoter activity analysis experiment on VvH3K4–5 showed that VvH3K4s may be regulated by H₂O₂. With H₂O₂ and Hypotaurine treatment, it was found that the expression pattern of most genes was opposite, and the expression level showed different expression trend with the extension of treatment time.

果实发育受到不同类型的表观遗传学的影响。组蛋白甲基化是表观遗传修饰的重要途径。基于保守域分析，从葡萄基因组中鉴定分离出8个H3K4甲基转移酶相关基因，命名为VvH3K4s ，根据系统发育关系可分为3类。转录组数据显示，VvH3K4-5在果实成熟期明显上调，其表达水平在'巨峰'和'丰早'之间存在显着差异。VvH3K4s启动子含有响应压力的顺式作用元件，表明它们可能参与代谢途径由 ROS 信号调节。VvH3K4-5的亚细胞定位实验和启动子活性分析实验表明， VvH3K4s可能受H ₂ O ₂的调控。用H ₂ O ₂和Hypotaurine处理发现大部分基因的表达模式相反，随着处理时间的延长，表达水平呈现不同的表达趋势。