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New chalcone derivatives as effective against SARS-CoV-2 agent
International Journal of Clinical Practice ( IF 2.2 ) Pub Date : 2021-09-14 , DOI: 10.1111/ijcp.14846
Nizami Duran 1 , M Fatih Polat 2 , Derya Anil Aktas 3 , M Abdullah Alagoz 4 , Emrah Ay 1 , Funda Cimen 1 , Erhan Tek 1 , Baris Anil 5 , Serdar Burmaoglu 5 , Oztekin Algul 6, 7
Affiliation  

Flavonoids and related compounds, such as quercetin-based antiviral drug Gene-Eden-VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The alkylated chalcones isolated from Angelica keiskei inhibit SARS-CoV proteases. In this study, we aimed to compare the anti-SARS CoV-2 activities of both newly synthesized chalcone derivatives and these two drugs.

中文翻译:

新的查尔酮衍生物对 SARS-CoV-2 药物有效

黄酮类化合物和相关化合物,例如基于槲皮素的抗病毒药物 Gene-Eden-VIR/Novirin,可抑制严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的蛋白酶。从当归 keiskei中分离出的烷基化查耳酮可抑制 SARS-CoV 蛋白酶。在这项研究中,我们旨在比较新合成的查尔酮衍生物和这两种药物的抗 SARS CoV-2 活性。
更新日期:2021-09-14
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