The association of Hashimoto thyroiditis and Graves’ disease with papillary, follicular, and medullary thyroid cancer has not been comprehensively investigated until now. This comparative clinicopathological study of consecutive patients thyroidectomized at a surgical referral center aimed to explore interdependencies between chronic autoimmune thyroiditis and thyroid cancer. Altogether, there were 852 (58.4%) patients with papillary thyroid cancer, 181 (12.4%) patients with follicular thyroid cancer, and 426 (29.2%) patients with sporadic medullary thyroid cancer, of whom 75 (5.1%) patients also had Hashimoto thyroiditis and 40 (2.7%) patients also had Graves’ disease. Patients with papillary (medians of 42 vs. 48 years; P =0.008) and follicular (medians of 33 vs. 63 years; P=0.022) thyroid cancer, unlike patients with medullary thyroid cancer (medians of 57.5 vs. 57 years; P=0.989), were younger at thyroidectomy when they had Hashimoto thyroiditis concomitantly. No such associations were seen with Graves’ disease. Primary thyroid cancers tended to be more localized in conjunction with Hashimoto thyroiditis, and less so with Graves’ disease, although patterns were not consistent across tumor types. In conclusion, Hashimoto thyroiditis, but not Graves’ disease, may be associated with differentiated (papillary and follicular) thyroid cancer but not with medullary thyroid cancer.

中文翻译：

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桥本甲状腺炎与Graves病合并分化型甲状腺髓样癌的临床意义

桥本甲状腺炎和格雷夫斯病与乳头状、滤泡状和髓样甲状腺癌的关系迄今尚未得到全面研究。这项对在外科转诊中心进行甲状腺切除术的连续患者进行的比较临床病理学研究旨在探索慢性自身免疫性甲状腺炎和甲状腺癌之间的相互依赖性。共有 852 名（58.4%）甲状腺乳头状癌患者，181 名（12.4%）甲状腺滤泡状癌患者，426 名（29.2%）散发性甲状腺髓样癌患者，其中 75 名（5.1%）患者同时患有桥本甲状腺炎和 40 名 (2.7%) 患者也患有格雷夫斯病。乳头状（中位数为 42 岁 vs. 48 岁；P = 0.008）和滤泡状（中位数为 33 岁 vs. 63 岁；P=0.022）甲状腺癌患者，与甲状腺髓样癌患者不同（中位值分别为 57.5 岁和 57 岁；P=0.989），当他们同时患有桥本甲状腺炎时，他们在甲状腺切除术中更年轻。Graves 病未见此类关联。原发性甲状腺癌更倾向于与桥本甲状腺炎相结合，而与 Graves 病相结合则较少，尽管不同肿瘤类型的模式并不一致。总之，桥本甲状腺炎而非 Graves 病可能与分化型（乳头状和滤泡状）甲状腺癌有关，但与甲状腺髓样癌无关。格雷夫斯病则更少，尽管肿瘤类型的模式并不一致。总之，桥本甲状腺炎而非 Graves 病可能与分化型（乳头状和滤泡状）甲状腺癌有关，但与甲状腺髓样癌无关。格雷夫斯病则更少，尽管肿瘤类型的模式并不一致。总之，桥本甲状腺炎而非 Graves 病可能与分化型（乳头状和滤泡状）甲状腺癌有关，但与甲状腺髓样癌无关。