A convenient approach for the synthesis of 3-difluoroalkyl phthalides has been developed from phthalaldehydic acids and difluoroenoxysilanes by using relatively inexpensive p-toluenesulfonic acid monohydrate (PTSA) as a catalyst. A series of 3-difluoroalkyl phthalides and cyclic difluoroalkyl ethers were obtained in up to 99% yield. The products obtained could be readily converted into difluoroalkyl phthalide derivatives by simple modifications.

中文翻译：

---

对甲苯磺酸催化邻苯二甲酸与二氟烯氧基硅烷的反应：获得 3-二氟烷基邻苯二甲酸酯

通过使用相对便宜的对甲苯磺酸一水合物 (PTSA) 作为催化剂，从邻苯二甲酸和二氟烯氧基硅烷开发了一种合成 3-二氟烷基苯酞的简便方法。以高达 99% 的产率获得了一系列 3-二氟烷基苯酞和环状二氟烷基醚。得到的产物可以通过简单的修饰很容易地转化为二氟烷基苯酞衍生物。