当前位置: X-MOL 学术Proc. Natl. Acad. Sci. U.S.A. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Differential involvement of CA2 in internally vs. externally driven hippocampal sequences [Letters (Online Only)]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2021-09-21 , DOI: 10.1073/pnas.2110671118
Andrew B Lehr 1, 2 , Tristan M Stöber 3, 4, 5
Affiliation  

MacDonald and Tonegawa (1) show that inhibiting projections from dorsal CA2 to CA1 impairs performance on a delayed spatial alternation task and destabilizes sequences of neural activity in CA1 (Fig. 1). Notably, the effect on behavior is only observed if CA2 inputs are inhibited during the delay, and the effect on activity sequences is stronger for the delay compared to track running.

中文翻译:

CA2 在内部与外部驱动的海马序列中的不同参与 [信件(仅限在线)]

MacDonald 和 Tonegawa ( 1 ) 表明,抑制从背侧 CA2 到 CA1 的投射会损害延迟空间交替任务的性能,并使 CA1 中的神经活动序列不稳定(图 1)。值得注意的是,只有在延迟期间抑制 CA2 输入时才会观察到对行为的影响,并且与轨道运行相比,延迟对活动序列的影响更强。
更新日期:2021-09-14
down
wechat
bug