In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities.

中文翻译：

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合成短缩脲的策略

近年来，已从入侵植物Hyptis brevipes Poit 中分离出15种 5,6-二氢-α-吡喃酮衍生物，它们带有独特的环丙烷或呋喃环，并命名为 brevipolides A–O ( 1 – 15 ) 。它们迷人的结构特征和有效的生物活性，包括对一系列人类癌细胞系的细胞毒性和对趋化因子受体 CCR5 的抑制，使它们成为有吸引力的合成靶点。这篇综述文章重点介绍了最近的合成方法并简要总结了它们的生物活性。