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Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
mBio ( IF 6.4 ) Pub Date : 2021-09-14 , DOI: 10.1128/mbio.02395-21 Wen Su 1 , Sin Fun Sia 1 , Aaron J Schmitz 2 , Traci L Bricker 3 , Tyler N Starr 4 , Allison J Greaney 4 , Jackson S Turner 2 , Bassem M Mohammed 2 , Zhuoming Liu 5 , Ka Tim Choy 1 , Tamarand L Darling 3 , Astha Joshi 3 , Ka Man Cheng 1 , Alvina Y L Wong 1 , Houda H Harastani 3 , John M Nicholls 6 , Sean P J Whelan 5 , Jesse D Bloom 4, 7 , Hui-Ling Yen 1 , Ali H Ellebedy 2 , Adrianus C M Boon 2, 3, 5
mBio ( IF 6.4 ) Pub Date : 2021-09-14 , DOI: 10.1128/mbio.02395-21 Wen Su 1 , Sin Fun Sia 1 , Aaron J Schmitz 2 , Traci L Bricker 3 , Tyler N Starr 4 , Allison J Greaney 4 , Jackson S Turner 2 , Bassem M Mohammed 2 , Zhuoming Liu 5 , Ka Tim Choy 1 , Tamarand L Darling 3 , Astha Joshi 3 , Ka Man Cheng 1 , Alvina Y L Wong 1 , Houda H Harastani 3 , John M Nicholls 6 , Sean P J Whelan 5 , Jesse D Bloom 4, 7 , Hui-Ling Yen 1 , Ali H Ellebedy 2 , Adrianus C M Boon 2, 3, 5
Affiliation
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is
the main target for neutralizing antibodies. These antibodies can be elicited through
immunization or passively transferred as therapeutics in the form of convalescent-phase
...
中文翻译：
中和靶向尖峰受体结合域的单克隆抗体赋予 Fc 受体独立保护，防止叙利亚仓鼠的 SARS-CoV-2 感染
严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 刺突蛋白是中和抗体的主要目标。这些抗体可以通过免疫产生，也可以作为治疗剂以恢复期的形式被动转移……
更新日期：2021-09-14
中文翻译：
中和靶向尖峰受体结合域的单克隆抗体赋予 Fc 受体独立保护，防止叙利亚仓鼠的 SARS-CoV-2 感染
严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 刺突蛋白是中和抗体的主要目标。这些抗体可以通过免疫产生，也可以作为治疗剂以恢复期的形式被动转移……
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