Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted In Vivo Inflammation Imaging,ACS Applied Polymer Materials

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Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted In Vivo Inflammation Imaging
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2021-09-13 , DOI: 10.1021/acsapm.1c01015
Shangyu Chen ₁ , Wansu Zhang ₁ , Xinyue Jiang ₁ , Yaqi Guo ₂ , Pengfei Sun ₁ , Wenjun Wang ₃ , Quli Fan ₁ , Wei Huang ₄

Affiliation

Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.

中文翻译：

用于靶向体内炎症成像的具有减少分子间相互作用的明亮 NIR-II 荧光小分子纳米颗粒

尽管基于生物相容性小分子的 NIR-II 荧光纳米粒子 (NPs) 在荧光成像 (FI) 中非常受欢迎，但由于显着的聚集引起的猝灭和大量的分子间相互作用，荧光量子产率相对较差。在此，我们方便地获得了由聚苯乙烯 (PS) 修饰的荧光团 (TQF-PS) 制成的明亮的 NIR-II 荧光小分子 NPs (TQFPNs)。我们制备的 PS 修饰的 NPs在体外显示出比非 PS 聚合物链 NPs (TQF@NPs) 高 3.2 倍的发射强度。最后，使用 TQFPNs 的类风湿性关节炎小鼠模型和肺炎小鼠模型的明亮和高分辨率 NIR-II FI 证明了其成功应用于靶向体内炎症成像。

更新日期：2021-10-08

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