Transport ions into cells through nanocarrier to achieve ion-interference therapy provides new inspiration for cancer treatment. In this work, a pH-targeted and NIR-responsive NaCl-nanocarrier is prepared using surfactant Vitamin E-O(EG₂-Glu) and modified with polydopamine (PDA) and pH-sensitive zwitterionic chitosan (ZWC). The NaCl-nanocarrier is decorated with NH₄HCO₃ and IR-780 to introduce near-infrared (NIR)-responsive performance and imaging. Once the NaCl-nanocarrier is exposed to NIR laser, the temperature rises rapidly because of the excellent photothermal conversion ability of PDA, then NH₄HCO₃ is decomposed into NH₃ and CO₂, which burst the nanocarrier, resulting in Cl⁻ and Na⁺ “bomb-like” release. This pH-targeted nanocarrier accumulates more at tumor site and when irradiating the site with NIR light, the temperature rises and excessive Cl⁻ and Na⁺ are released to destroy the ion homeostasis and inhibit tumor growth effectively. Through this strategy, the unique combination of ion interference therapy and photothermal therapy is achieved.

通过纳米载体将离子输送到细胞中，实现离子干扰治疗，为癌症治疗提供了新的启示。_{在这项工作中，使用表面活性剂维生素 EO(EG 2} -Glu)制备了一种 pH 靶向和 NIR 响应的 NaCl 纳米载体，并用聚多巴胺 (PDA) 和 pH 敏感的两性离子壳聚糖 (ZWC) 进行了改性。NaCl 纳米载体用 NH ₄ HCO ₃和 IR-780 装饰，以引入近红外 (NIR) 响应性能和成像。一旦NaCl-纳米载体暴露于NIR激光下，由于PDA优异的光热转换能力，温度迅速升高，然后NH ₄ HCO ₃分解为NH ₃和CO ₂，它使纳米载体爆裂，导致Cl ^-和Na ⁺ “炸弹状”释放。这种以pH为目标的纳米载体在肿瘤部位积累更多，当用近红外光照射该部位时，温度升高，释放出过量的Cl ^-和Na ⁺，从而破坏离子稳态并有效抑制肿瘤生长。通过这种策略，实现了离子干涉疗法和光热疗法的独特结合。