Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1,The Journal of Nutritional Biochemistry

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Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1
The Journal of Nutritional Biochemistry ( IF 4.8 ) Pub Date : 2021-09-14 , DOI: 10.1016/j.jnutbio.2021.108862
Jing Li ₁ , Yingjiang Zhang ₂ , Xin Zeng ₂ , Yahong Cheng ₂ , Liu Tang ₂ , Ding Hong ₂ , Xiaolong Yang ₃

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Lycopene (Ly) is a kind of hydrocarbon, which belongs to the family of tetraterpene carotene and exists in red fruits and vegetables. The decrease of capillary density and blood flow with age is a significant reason for the increase of mortality and morbidity. Herein, our study aims to explore the effects of Ly (a bioactive food compound) on vascular aging and and its potential mechanisms. The cytological results showed that Ly could promote the proliferation of human umbilical vein endothelial cell (HUVECs) and enhance the ability of HUVECs to form capillary-like structures. Furthermore, the expression of SIRT1 in aged HUVECs was up-regulated. , aging rats showed signs of insulin resistance and blood vessel damage. Additionally, the capillary density and blood flow were reduced during the vascular aging process in both D‐gal‐induced and naturally aging muscle. However, when Ly was given, these conditions could be reversed. Simultaneously, the contents of ATP, lactic acid and pyruvic acid were determined, and it was found that Ly could promote angiogenesis by increasing the utilization rate of glucose and promoting energy metabolism. Finally, in the insulin resistance cell model, we knocked down the SIRT1 and administrated with Ly, and found that it couldn't restore insulin transdution. In conclusion, all the data in this study demonstrate that Ly could reactivate SIRT1 and improve insulin resistance, which was a reversible cause of vascular aging.

中文翻译：

番茄红素通过激活 SIRT1 改善胰岛素抵抗并增加衰老过程中的肌肉毛细血管密度

番茄红素（Ly）是一种碳氢化合物，属于四萜类胡萝卜素家族，存在于红色水果和蔬菜中。随着年龄的增长，毛细血管密度和血流量降低是死亡率和发病率增加的重要原因。在此，我们的研究旨在探讨Ly（一种生物活性食物化合物）对血管老化的影响及其潜在机制。细胞学结果显示，Ly能够促进人脐静脉内皮细胞（HUVECs）增殖，增强HUVECs形成毛细血管样结构的能力。此外，老年 HUVEC 中 SIRT1 的表达上调。，衰老的老鼠表现出胰岛素抵抗和血管损伤的迹象。此外，在 D-gal 诱导的肌肉和自然老化的肌肉的血管老化过程中，毛细血管密度和血流量均减少。然而，当给予 Ly 时，这些条件可能会逆转。同时测定ATP、乳酸和丙酮酸的含量，发现Ly可以通过提高葡萄糖利用率、促进能量代谢来促进血管生成。最后，在胰岛素抵抗细胞模型中，我们敲低SIRT1并给予Ly，发现它无法恢复胰岛素转导。总之，本研究中的所有数据都表明 Ly 可以重新激活 SIRT1 并改善胰岛素抵抗，这是血管老化的可逆原因。

更新日期：2021-09-14

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