For the past 2 years, the coronavirus responsible for the COVID-19 infection has become a world pandemic, ruining the lives and economies of several nations in the world. This has scaled up research on the virus and the resulting infection with the goal of developing new vaccines and therapies. Natural products are known to be a rich source of lead compounds for drug discovery, including against infectious diseases caused by microbes (viruses, bacteria and fungi). In this review article, we conducted a literature survey aimed at identifying natural products with inhibitory concentrations against the coronaviruses or their target proteins, which lie below 10 µM. This led to the identification of 42 compounds belonging to the alkaloid, flavonoid, terpenoid, phenolic, xanthone and saponin classes. The cut off concentration of 10 µM was to limit the study to the most potent chemical entities, which could be developed into therapies against the viral infection to make a contribution towards limiting the spread of the disease.

在过去的两年里，导致 COVID-19 感染的冠状病毒已成为世界大流行病，破坏了世界上多个国家的生活和经济。这扩大了对病毒和由此产生的感染的研究，目标是开发新的疫苗和疗法。众所周知，天然产物是药物发现的先导化合物的丰富来源，包括针对微生物（病毒、细菌和真菌）引起的传染病。在这篇综述文章中，我们进行了一项文献调查，旨在识别对冠状病毒或其靶蛋白具有抑制浓度（低于 10 µM）的天然产物。由此鉴定出 42 种属于生物碱、黄酮类、萜类、酚类、氧杂蒽酮和皂苷类的化合物。10 µM 的截止浓度是为了将研究限制在最有效的化学实体上，这些化学实体可以开发成针对病毒感染的疗法，从而为限制疾病的传播做出贡献。