Purpose

A link between maternal thyroid dysfunction during pregnancy and the risk of cognitive and behavioral problems in the offspring has previously been established; however, the potential effects of maternal thyroid autoimmunity on neurodevelopment in the absence of maternal hypothyroidism are less clear. The present review aims to highlight the gaps in knowledge in this regard and provide a thorough assessment of relevant literature.

Method

Related keywords searched in MEDLINE, Web of Science, and Scopus till January 2021.

Results

There is some evidence that neuropsychological and intellectual developments of offspring are adversely affected by maternal thyroid autoimmunity, although the results of available studies are not concordant. The tools and measurements that have been applied in different studies to assess neurodevelopment or IQ vary widely and the children born to mothers with thyroid autoimmunity have been assessed at different chronological stages of life. Such variations may explain some of the differences across studies. In addition, the definition of thyroid autoimmunity has been based on TPOAb cut points provided by manufacturers in most cases, but it is preferable to define these values based on age, trimester, and method-specific reference ranges.

Conclusion

Well-designed studies are needed to assess verbal and non-verbal neurocognition of offspring born to mothers with autoimmune thyroid disease before or during pregnancy.

中文翻译：

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甲状腺功能正常孕妇的 TPO 抗体和后代的认知能力：重点综述

目的

先前已经确定了怀孕期间母体甲状腺功能障碍与后代认知和行为问题风险之间的联系；然而，在没有母体甲状腺功能减退的情况下，母体甲状腺自身免疫对神经发育的潜在影响尚不清楚。本综述旨在突出这方面的知识空白，并对相关文献进行全面评估。

方法

相关关键词在 MEDLINE、Web of Science 和 Scopus 中检索到 2021 年 1 月。

结果

有一些证据表明，后代的神经心理学和智力发育受到母体甲状腺自身免疫的不利影响，尽管现有研究的结果并不一致。用于评估神经发育或智商的不同研究的工具和测量方法差异很大，患有甲状腺自身免疫的母亲所生的孩子在生命的不同时间阶段进行了评估。这种变化可以解释研究之间的一些差异。此外，在大多数情况下，甲状腺自身免疫的定义是基于制造商提供的 TPOAb 切点，但最好根据年龄、孕期和特定方法的参考范围来定义这些值。

结论

需要精心设计的研究来评估患有自身免疫性甲状腺疾病的母亲在怀孕前或怀孕期间所生后代的语言和非语言神经认知。