A novel series of phenoxymethybenzoimidazole derivatives (9a-n) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC₅₀ values in the range of 6.31 to 49.89 μM compared to standard drug acarbose (IC₅₀ = 750.0 ± 10.0 μM). Enzyme kinetic studies on 9c, 9g, and 9m as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzoimidazole and triazole rings of the synthesized compounds to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor.

合理设计、合成了一系列新的苯氧基甲基苯并咪唑衍生物（9a-n），并评估了它们的α-糖苷酶抑制活性。_{与标准药物阿卡波糖（IC 50}  = 750.0 ± 10.0 μM）相比，所有测试的化合物都显示出有希望的 α-糖苷酶抑制潜力，IC ₅₀值在 6.31 至 49.89 μM 范围内。9c、9g和9m的酶动力学研究因为最有效的化合物表明这些化合物是 α-糖苷酶的非竞争性抑制剂。对接研究证实了合成化合物的苯并咪唑和三唑环在适当地适应α-糖苷酶活性位点的重要作用。这项研究表明，这种支架可以被认为是一种高效的α-糖苷酶抑制剂。