In 2017, the government of Ukraine initiated its ART Optimization Initiative, revising its national antiretroviral therapy (ART) guidelines and embracing Dolutegravir (DTG) as a backbone of first-line ART regimens. A cross-sectional survey of 464 ART patients from 22 large ART clinics was carried out in mid-2019. The survey assessed patient-reported outcomes (PROS) including treatment satisfaction, physical health, mental health, depression, side effects of ART, and adherence. The associations between ART regimen and PROs were assessed using bivariable and multivariable generalized estimating equations (GEE) models. More than half (55.6%) of the patients were satisfied with their current ART regimen. Less than a half (45.3%) considered their physical health as good while only 36.9% rated their mental health as good, 21.3% reported moderate or severe depression, 82.3% reported no side effect in the past 4 weeks, and 44.4% reported not missing ART medication in the past month. In adjusted analysis, patients starting ART with DTG had higher treatment satisfaction compared to people continuing LPV-based regimens (aOR = 0.49, 95% confidence interval: 0.22–0.90). Also in adjusted analyses, unemployment, low income, and history of injection drug use were associated with unfavorable PROs. While the results indicate modestly favorable effects of ART Optimization, there is clearly a need for complementary interventions to improve PROs among disadvantaged ART patients in Ukraine.

2017 年，乌克兰政府启动了 ART 优化计划，修订了国家抗逆转录病毒治疗 (ART) 指南，并将 Dolutegravir (DTG) 作为一线 ART 治疗方案的支柱。2019 年年中对来自 22 家大型 ART 诊所的 464 名 ART 患者进行了横断面调查。该调查评估了患者报告的结果 (PROS)，包括治疗满意度、身体健康、心理健康、抑郁、ART 的副作用和依从性。使用双变量和多变量广义估计方程 (GEE) 模型评估 ART 方案和 PRO 之间的关联。超过一半 (55.6%) 的患者对他们目前的 ART 方案感到满意。不到一半（45.3%）的人认为他们的身体健康状况良好，而只有 36.9% 的人认为他们的心理健康状况良好，21。3% 报告中度或重度抑郁症，82.3% 报告在过去 4 周内没有副作用，44.4% 报告在过去一个月内没有错过抗逆转录病毒药物治疗。在调整后的分析中，与继续使用基于 LPV 的方案的人相比，使用 DTG 开始 ART 的患者具有更高的治疗满意度（aOR = 0.49，95% 置信区间：0.22-0.90）。同样在调整后的分析中，失业、低收入和注射吸毒史与不利的 PRO 相关。虽然结果表明 ART 优化的适度有利效果，但显然需要补充干预措施来改善乌克兰处于不利地位的 ART 患者的 PROs。与继续使用基于 LPV 的方案的人相比，使用 DTG 开始 ART 的患者具有更高的治疗满意度（aOR = 0.49，95% 置信区间：0.22-0.90）。同样在调整后的分析中，失业、低收入和注射吸毒史与不利的 PRO 相关。虽然结果表明 ART 优化的适度有利效果，但显然需要补充干预措施来改善乌克兰处于不利地位的 ART 患者的 PROs。与继续使用基于 LPV 的方案的人相比，使用 DTG 开始 ART 的患者具有更高的治疗满意度（aOR = 0.49，95% 置信区间：0.22-0.90）。同样在调整后的分析中，失业、低收入和注射吸毒史与不利的 PRO 相关。虽然结果表明 ART 优化的适度有利效果，但显然需要补充干预措施来改善乌克兰处于不利地位的 ART 患者的 PROs。