Along with structural and non-structural proteins, SARS-CoV-2, SARS-CoV, and MERS-CoV can also express accessory proteins. During the past few years, there have been only a few studies focusing on this set of proteins. Despite available data on these proteins, there are still a lot of questions on the functions of these proteins during infection that must be answered. With these three betacoronaviruses causing outbreaks in humans during the past few years, the need for a thorough understanding of the roles of these proteins is becoming more important and relevant. This review provides a survey of the existing knowledge on the roles of these proteins during infection. In addition to current evidence, a more comprehensive view of the functions of these proteins is presented together with their potential as therapeutic targets, which were determined by using different bioinformatics platforms. This information may help test effective therapeutic regimens against these viruses and in preparing for future pandemics.

中文翻译：

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SARS-COV-2、SARS-COV 和 MERS-COV β 冠状病毒辅助蛋白的多样性。


除了结构蛋白和非结构蛋白之外，SARS-CoV-2、SARS-CoV 和 MERS-CoV 还可以表达辅助蛋白。在过去的几年中，只有少数研究集中在这组蛋白质上。尽管有关于这些蛋白质的可用数据，但关于这些蛋白质在感染期间的功能仍有许多问题需要解答。随着这三种β冠状病毒在过去几年中在人类中引起爆发，彻底了解这些蛋白质的作用的需要变得更加重要和相关。本综述对这些蛋白质在感染过程中的作用的现有知识进行了调查。除了当前的证据之外，还对这些蛋白质的功能及其作为治疗靶点的潜力进行了更全面的了解，这是通过使用不同的生物信息学平台确定的。这些信息可能有助于测试针对这些病毒的有效治疗方案，并为未来的大流行做好准备。