There is an increase in the incidence of inflammatory eye diseases worldwide. Several dysregulated inflammatory pathways, including the NOD-like receptor protein 3 (NLRP3) inflammasome, have been reported to contribute significantly to the pathogenesis and progression of ophthalmic diseases. Although the available allopathic/ conventional medicine has demonstrated effectiveness in managing eye diseases, there is an ongoing global demand for alternative therapeutics with minimal adverse drug reactions, easy availability, increase in patient compliance, and better disease outcomes. Therefore, several studies are investigating the utilization of natural products and herbal formulations in impeding inflammatory pathways, including the NLRP3 inflammasome, in order to prevent or manage eye diseases. In the present review, we highlight the recently reported inflammatory pathways with special emphasis on NLRP3 Inflammasomes involved in the development of eye diseases. Furthermore, we present a variety of natural products and phytochemicals that were reported to interfere with these pathways and their underlying mechanisms of action. These natural products represent potential therapeutic applications for the treatment of several inflammatory eye diseases.

中文翻译：

---

炎症通路的治疗靶向，强调天然产物的 NLRP3 炎症小体：一种治疗炎症性眼病的新方法。

全世界炎症性眼病的发病率呈上升趋势。据报道，几种失调的炎症通路，包括 NOD 样受体蛋白 3 (NLRP3) 炎性体，对眼科疾病的发病机制和进展有显着贡献。尽管现有的对抗疗法/常规药物已证明在治疗眼部疾病方面有效，但全球仍需要具有最小的药物不良反应、易于获得、提高患者依从性和更好的疾病结果的替代疗法。因此，一些研究正在研究利用天然产物和草药制剂来阻止炎症通路，包括 NLRP3 炎症小体，以预防或控制眼部疾病。在本次审查中，我们重点介绍了最近报道的炎症通路，特别强调了参与眼病发展的 NLRP3 炎症小体。此外，我们还介绍了据报道会干扰这些途径及其潜在作用机制的各种天然产物和植物化学物质。这些天然产物代表了治疗几种炎症性眼病的潜在治疗应用。