Atherosclerosis and its complications diseases remain leading causes of cardiovascular morbidity and mortality, bringing a massive burden on public health worldwide. Atherosclerosis is recognized as chronic inflammation, and involves several highly correlated processes, including lipid metabolism dysfunction, endothelial cell dysfunction, inflammation, oxidative stress, vascular smooth muscle cell activation, platelet activation, thrombosis, altered matrix metabolism, and vascular remodeling. Within the past few decades, accumulating evidence has shown that the Yes-associated protein (YAP), the major effector of the Hippo pathway, can play a crucial role in pathogenesis and development of atherosclerosis. Activation of YAP-related pathways, which are induced by alerting flow pattern and matrix stiffness among others, can regulate processes including vascular endothelial cell dysfunction, monocyte infiltration, and smooth muscle cell migration, which contribute to atherosclerotic lesion formation. Further, YAP potentially modulates atherosclerotic complications such as vascular calcification and intraplaque hemorrhage, which require further investigation. Here, we summarized the relevant literature to outline current findings detailing the relationship between of YAP and atherosclerosis and highlight areas for future research.

中文翻译：

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动脉粥样硬化和相关并发症中的 Yes 相关蛋白：一个需要进一步探索的潜在治疗靶点。

动脉粥样硬化及其并发症仍然是心血管发病率和死亡率的主要原因，给全世界的公共卫生带来了巨大的负担。动脉粥样硬化被认为​​是慢性炎症，涉及几个高度相关的过程，包括脂质代谢功能障碍、内皮细胞功能障碍、炎症、氧化应激、血管平滑肌细胞活化、血小板活化、血栓形成、基质代谢改变和血管重塑。在过去的几十年里，越来越多的证据表明，作为 Hippo 通路的主要效应物 Yes 相关蛋白 (YAP) 可以在动脉粥样硬化的发病机制和发展中发挥关键作用。YAP 相关通路的激活，这是由警报流动模式和基质刚度等引起的，可以调节包括血管内皮细胞功能障碍、单核细胞浸润和平滑肌细胞迁移在内的过程，这些过程有助于动脉粥样硬化病变的形成。此外，YAP 可能调节动脉粥样硬化并发症，如血管钙化和斑块内出血，这需要进一步研究。在这里，我们总结了相关文献，以概述详细说明 YAP 与动脉粥样硬化之间关系的当前发现，并突出未来研究的领域。