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Oocytes With Smooth Endoplasmic Reticulum Aggregates Are Not Associated With Impaired Reproductive Outcomes: A Matched Retrospective Cohort Study.
Frontiers in Endocrinology ( IF 3.9 ) Pub Date : 2021-08-26 , DOI: 10.3389/fendo.2021.688967
Jian Xu 1 , Li Yang 1 , Zhi-Heng Chen 1 , Min-Na Yin 1 , Juan Chen 1 , Ling Sun 1
Affiliation  

Objective To investigate whether the reproductive outcomes of oocytes with smooth endoplasmic reticulum aggregates (SERa) are impaired. Methods A total of 2893 intracytoplasmic sperm injection (ICSI) cycles were performed between January 2010 and December 2019 in our center. In 43 transfer cycles, transferred embryos were totally derived from SERa+ oocytes. Each of the 43 cycles was matched with a separate control subject from SERa- patient of the same age ( ± 1 year), embryo condition, main causes of infertility, type of protocols used for fresh or frozen embryo transfer cycles. The clinical pregnancy, implantation, ectopic pregnancy and live birth rate were compared between the two groups. Results 43 embryo transfer cycles from SERa- patient were matched to the 43 transferred cycles with pure SERa+ oocytes derived embryos. No significant difference was observed in clinical pregnancy rate (55.81% vs. 65.11%, p=0.5081), implantation rate (47.89% vs. 50.70%, p=0.8667) and live birth rate (48.84% vs. 55.81%, p=0.6659) between the SERa+ oocyte group and the matched group. No congenital birth defects were found in the two groups. Conclusion Our results suggest that the implantation, clinical pregnancy, live birth and birth defects rate of embryos derived from oocytes with SERa are not impaired.

中文翻译:

具有光滑内质网聚集体的卵母细胞与受损的生殖结果无关:一项匹配的回顾性队列研究。

目的探讨光滑内质网聚集体(SERa)卵母细胞的生殖结局是否受损。方法 2010 年 1 月至 2019 年 12 月期间,我中心共进行了 2893 次卵胞浆内单精子注射(ICSI)周期。在 43 个移植周期中,移植的胚胎完全来自 SERa+ 卵母细胞。43 个周期中的每个周期都与来自相同年龄(± 1 岁)、胚胎状况、不孕的主要原因、用于新鲜或冷冻胚胎移植周期的协议类型的 SERa 患者的单独对照对象相匹配。比较两组的临床妊娠、着床、异位妊娠和活产率。结果 来自 SERa- 患者的 43 个胚胎移植周期与具有纯 SERa+ 卵母细胞衍生胚胎的 43 个移植周期相匹配。临床妊娠率(55.81% vs. 65.11%, p=0.5081)、着床率(47.89% vs. 50.70%, p=0.8667)和活产率(48.84% vs. 55.81%, p= 0.6659)在SERa+卵母细胞组和匹配组之间。两组均未发现先天性出生缺陷。结论 我们的研究结果表明,SERa 卵母细胞的胚胎着床率、临床妊娠率、活产率和出生缺陷率均未受损。
更新日期:2021-08-26
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