Epilepsy is one of the most common debilitating neurological disorders that lead to severe socio-cognitive dysfunction. While there are currently more than 30 antiseizure medications available for the treatment and prevention of seizures, none address the prevention of epileptogenesis that leading to the development of epilepsy following a potential brain insult. Hence, there is a growing need for the identification of accurate biomarkers of epileptogenesis that enable the prediction of epilepsy following a known brain insult. Although recent studies using various neuroimages and electroencephalography have found promising biomarkers of epileptogenesis, their utility needs to be further validated in larger clinical trials. In this literature review, we searched the Medline, Pubmed, and Embase databases using the following search algorithm: "epileptogenesis" and "biomarker" and "EEG" or "electroencephalography" or "neuroimaging" limited to publications in English. We presented a comprehensive overview of recent innovations in the role of neuroimaging and EEG in identifying reliable biomarkers of epileptogenesis.

中文翻译：

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癫痫发生的神经影像学和脑电图生物标志物的更新：文献综述。

癫痫是最常见的使人衰弱的神经系统疾病之一，可导致严重的社会认知功能障碍。虽然目前有超过 30 种抗癫痫药物可用于治疗和预防癫痫发作，但没有一种能预防癫痫发生，而癫痫发生会导致潜在的脑损伤后癫痫的发展。因此，越来越需要鉴定癫痫发生的准确生物标志物，以预测已知脑损伤后的癫痫。虽然最近使用各种神经图像和脑电图的研究发现了有希望的癫痫发生生物标志物，但它们的效用需要在更大的临床试验中进一步验证。在这篇文献综述中，我们使用以下搜索算法搜索了 Medline、Pubmed 和 Embase 数据库：“